The effects of neurotensin on GABA and acetylcholine release in the dorsal striatum of the rat: an in vivo microdialysis study
- PMID: 1504761
- DOI: 10.1016/0006-8993(92)90765-2
The effects of neurotensin on GABA and acetylcholine release in the dorsal striatum of the rat: an in vivo microdialysis study
Abstract
The effects of local perfusion with the tridecapeptide neurotensin (NT) on endogenous gamma-aminobutyric acid (GABA), acetylcholine (ACh) and choline release in the dorsal neostriatum were monitored using in vivo microdialysis in the halothane anaesthetized rat. The results show that NT (10 and 1000 nM) differentially regulates striatal GABA release without significantly influencing the release of either striatal ACh or choline. NT increased striatal GABA release both in the absence and presence of the ACh esterase inhibitor neostigmine (neo; 10 microM) in the perfusion medium. However, both basal GABA levels and responsitivity to NT were elevated in the presence of neo. The NT induced increase in striatal GABA release was reversed by the addition of tetrodotoxin (TTX; 1 micron) to the perfusion medium. These data suggest that (1) NT may play a role in modulating GABAergic neurotransmission in the dorsal neostriatum and (2) that the increase in GABA release may occur independently of an increase in the cholinergic component in the dorsal neostriatum, possibly via high affinity NT receptors located on striatal GABAergic neurons.
Similar articles
-
Differential effects of intrastriatal neurotensin(1-13) and neurotensin(8-13) on striatal dopamine and pallidal GABA release. A dual-probe microdialysis study in the awake rat.Eur J Neurosci. 1997 Sep;9(9):1838-46. doi: 10.1111/j.1460-9568.1997.tb00750.x. Eur J Neurosci. 1997. PMID: 9383206
-
Neurotensin modulation of acetylcholine and GABA release from the rat hippocampus: an in vivo microdialysis study.Neurochem Int. 1998 Oct;33(4):335-40. doi: 10.1016/s0197-0186(98)00036-9. Neurochem Int. 1998. PMID: 9840224
-
Neurotensin regulation of endogenous acetylcholine release from rat striatal slices is independent of dopaminergic tone.J Neurochem. 1991 Feb;56(2):651-7. doi: 10.1111/j.1471-4159.1991.tb08199.x. J Neurochem. 1991. PMID: 1899109
-
Mesolimbic dopamine and cortico-accumbens glutamate afferents as major targets for the regulation of the ventral striato-pallidal GABA pathways by neurotensin peptides.Brain Res Rev. 2007 Aug;55(1):144-54. doi: 10.1016/j.brainresrev.2007.03.006. Epub 2007 Mar 24. Brain Res Rev. 2007. PMID: 17448541 Review.
-
Role of GABA in the striatal output system: globus pallidus, nucleus entopeduncularis, substantia nigra and nucleus subthalamicus.Adv Biochem Psychopharmacol. 1981;30:165-86. Adv Biochem Psychopharmacol. 1981. PMID: 7036675 Review. No abstract available.
Cited by
-
Evidence for a substrate of neuronal plasticity based on pre- and postsynaptic neurotensin-dopamine receptor interactions in the neostriatum.Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5591-5. doi: 10.1073/pnas.89.12.5591. Proc Natl Acad Sci U S A. 1992. PMID: 1535159 Free PMC article.
-
The striatal neurotensin receptor modulates striatal and pallidal glutamate and GABA release: functional evidence for a pallidal glutamate-GABA interaction via the pallidal-subthalamic nucleus loop.J Neurosci. 1998 Sep 1;18(17):6977-89. doi: 10.1523/JNEUROSCI.18-17-06977.1998. J Neurosci. 1998. PMID: 9712666 Free PMC article.
-
Activation of neurotensin receptor 1 facilitates neuronal excitability and spatial learning and memory in the entorhinal cortex: beneficial actions in an Alzheimer's disease model.J Neurosci. 2014 May 14;34(20):7027-42. doi: 10.1523/JNEUROSCI.0408-14.2014. J Neurosci. 2014. PMID: 24828655 Free PMC article.
-
The role of neurotensin in central nervous system pathophysiology: what is the evidence?J Psychiatry Neurosci. 2006 Jul;31(4):229-45. J Psychiatry Neurosci. 2006. PMID: 16862241 Free PMC article. Review.
-
Receptor-receptor interactions as studied with microdialysis. Focus on NTR/D2 interactions in the basal ganglia.J Neural Transm (Vienna). 2007 Jan;114(1):105-13. doi: 10.1007/s00702-006-0558-7. Epub 2006 Sep 19. J Neural Transm (Vienna). 2007. PMID: 16983483 Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Research Materials
