doi: 10.1126/science.1091334.
Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria
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- PMID: 15016999
- DOI: 10.1126/science.1091334
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Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria
Science.
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Abstract
The enormous number of commensal bacteria in the lower intestine of vertebrates share abundant molecular patterns used for innate immune recognition of pathogenic bacteria. We show that, even though commensals are rapidly killed by macrophages, intestinal dendritic cells (DCs) can retain small numbers of live commensals for several days. This allows DCs to selectively induce IgA, which helps protect against mucosal penetration by commensals. The commensal-loaded DCs are restricted to the mucosal immune compartment by the mesenteric lymph nodes, which ensures that immune responses to commensal bacteria are induced locally, without potentially damaging systemic immune responses.
Comment in
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Immunology. Keeping the gut microflora at bay.Science. 2004 Mar 12;303(5664):1624-5. doi: 10.1126/science.1096222. Science. 2004. PMID: 15016988 No abstract available.
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