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. 1992 Dec;8(12):2063-71.
doi: 10.1089/aid.1992.8.2063.

Expression of human CD4 in transgenic mice does not confer sensitivity to human immunodeficiency virus infection

P Lorès  1 , V Boucher, C Mackay, M Pla, H Von Boehmer, J Jami, F Barré-Sinoussi, J C Weill
Affiliations

Expression of human CD4 in transgenic mice does not confer sensitivity to human immunodeficiency virus infection

P Lorès et al. AIDS Res Hum Retroviruses. 1992 Dec.

Abstract

Transfection of the human CD4 molecule into mouse cells does not confer susceptibility to human immunodeficiency virus type 1 (HIV-1) infection. Expression of the human CD4 molecule in transgenic mice was seen to offer some new possibilities. However, transgenic mouse T cells expressing either the human CD4 receptor, or a hybrid human/mouse CD4 receptor alone or in conjunction with human major histocompatibility complex class I molecules, were refractory to in vitro HIV-1 infection. In addition, no infection was observed after in vivo HIV inoculation to mice of these various transgenic lines. Injection of recombinant gp160 viral protein to the transgenic mice did not alter their T and B cell populations. The existence of a dominant block in mouse cells that prevents HIV entry is discussed.

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