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Review
. 2003 Jun;7(2):191-204.

Targeting proteasome inhibition in hematologic malignancies

Teru Hideshima  1 , Paul G Richardson, Kenneth C Anderson
Affiliations
  • PMID: 14763162
Review

Targeting proteasome inhibition in hematologic malignancies

Teru Hideshima et al. Rev Clin Exp Hematol. 2003 Jun.

Abstract

Proteasome inhibitors represent potential novel anti-cancer therapy. These agents inhibit the degradation of multi-ubiquitinated target proteins mediating cell cycle progression, apoptosis, NF-kappa B activation, inflammation, cell cycle regulatory proteins such as cyclins and cyclin dependent kinase inhibitors, as well as immune surveillance; and regulate anti-apoptosis and cell cycle progression. Proteasome inhibitors also directly induce caspase-dependent apoptosis of tumor cells, despite the accumulation of p21 and p27 and irrespective of the p53 wild type or mutant status. Recent studies demonstrate that PS-341, peptide boronate, has remarkable anti-tumor activity in preclinical and clinical studies, not only in multiple myeloma but also in other malignancies.

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