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. 2004 Feb;6(2):154-61.
doi: 10.1038/ncb1094. Epub 2004 Jan 25.

FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly

Donna J Webb  1 , Karen Donais, Leanna A Whitmore, Sheila M Thomas, Christopher E Turner, J Thomas Parsons, Alan F Horwitz
Affiliations

FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly

Donna J Webb et al. Nat Cell Biol. 2004 Feb.

Abstract

Cell migration is a complex, highly regulated process that involves the continuous formation and disassembly of adhesions (adhesion turnover). Adhesion formation takes place at the leading edge of protrusions, whereas disassembly occurs both at the cell rear and at the base of protrusions. Despite the importance of these processes in migration, the mechanisms that regulate adhesion formation and disassembly remain largely unknown. Here we develop quantitative assays to measure the rate of incorporation of molecules into adhesions and the departure of these proteins from adhesions. Using these assays, we show that kinases and adaptor molecules, including focal adhesion kinase (FAK), Src, p130CAS, paxillin, extracellular signal-regulated kinase (ERK) and myosin light-chain kinase (MLCK) are critical for adhesion turnover at the cell front, a process central to migration.

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