doi: 10.1016/S0140-6736(03)15332-9.
Proportion of tuberculosis transmission that takes place in households in a high-incidence area
Affiliations
- PMID: 14738796
- DOI: 10.1016/S0140-6736(03)15332-9
Item in Clipboard
Proportion of tuberculosis transmission that takes place in households in a high-incidence area
Lancet.
.
Abstract
The prevalence of infection among household contacts of people with tuberculosis is high. This information frequently guides active case finding. We analysed DNA fingerprints of Mycobacterium tuberculosis from 765 tuberculosis patients in Ravensmead and Uitsig, adjacent suburbs of Cape Town, South Africa. In 129 households in which DNA fingerprints were available for more than one patient, we identified 313 patients, of whom 145 (46%) had a fingerprint pattern matching that of another member of the household. The proportion of transmission in the community that took place in the household was 19%, and therefore, in this high-incidence area, tuberculosis transmission occurs mainly outside the household.
Comment in
-
Transmission of tuberculosis within households.Lancet. 2004 Mar 27;363(9414):1075-6; author reply 1076. doi: 10.1016/S0140-6736(04)15852-2. Lancet. 2004. PMID: 15051292 No abstract available.
Similar articles
-
Tuberculosis transmission patterns in a high-incidence area: a spatial analysis.Int J Tuberc Lung Dis. 2003 Mar;7(3):271-7. Int J Tuberc Lung Dis. 2003. PMID: 12661843
-
Unexpectedly high strain diversity of Mycobacterium tuberculosis in a high-incidence community.S Afr Med J. 1996 Jan;86(1):45-9. S Afr Med J. 1996. PMID: 8685781
-
Transmission of tuberculosis in a high incidence urban community in South Africa.Int J Epidemiol. 2004 Apr;33(2):351-7. doi: 10.1093/ije/dyh021. Int J Epidemiol. 2004. PMID: 15082639
-
Genetic fingerprinting in the study of tuberculosis transmission.CMAJ. 1999 Nov 2;161(9):1165-9. CMAJ. 1999. PMID: 10569108 Free PMC article. Review. No abstract available.
-
Molecular epidemiology of tuberculosis.N Engl J Med. 2003 Sep 18;349(12):1149-56. doi: 10.1056/NEJMra021964. N Engl J Med. 2003. PMID: 13679530 Review. No abstract available.
Cited by
-
Modeling the role of public transportation in sustaining tuberculosis transmission in South Africa.Am J Epidemiol. 2013 Mar 15;177(6):556-61. doi: 10.1093/aje/kws331. Epub 2013 Feb 18. Am J Epidemiol. 2013. PMID: 23423215 Free PMC article.
-
Infection status of contacts is not associated with severity of TB in the index case.Int J Tuberc Lung Dis. 2021 Mar 1;25(3):237-240. doi: 10.5588/ijtld.20.0700. Int J Tuberc Lung Dis. 2021. PMID: 33688815 Free PMC article. No abstract available.
-
Incidence of tuberculosis and the predictive value of ELISPOT and Mantoux tests in Gambian case contacts.PLoS One. 2008 Jan 2;3(1):e1379. doi: 10.1371/journal.pone.0001379. PLoS One. 2008. PMID: 18167540 Free PMC article.
-
Human lung epithelial cells contain Mycobacterium tuberculosis in a late endosomal vacuole and are efficiently recognized by CD8⁺ T cells.PLoS One. 2014 May 14;9(5):e97515. doi: 10.1371/journal.pone.0097515. eCollection 2014. PLoS One. 2014. PMID: 24828674 Free PMC article.
-
Infection control and tuberculosis among health care workers in Viet Nam, 2009-2013: a cross-sectional survey.BMC Infect Dis. 2016 Nov 10;16(1):664. doi: 10.1186/s12879-016-1993-1. BMC Infect Dis. 2016. PMID: 27832744 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
