Review
doi: 10.1016/j.cub.2003.12.051.
Molecular chaperones: structure of a protein disaggregase
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- PMID: 14738756
- DOI: 10.1016/j.cub.2003.12.051
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Review
Molecular chaperones: structure of a protein disaggregase
Curr Biol.
.
Free article
Abstract
The ring-forming molecular chaperone Hsp104/ClpB is a member of the AAA+ protein family which rescues proteins from aggregated states. The newly determined crystal structure of ClpB provides new insights into the mechanism of protein disaggregation, suggesting a crowbar activity mediated by a unique coiled-coil domain.
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