Review
doi: 10.1038/sj.ijo.0802503.
Role of Ser/Thr kinases in the uncoupling of insulin signaling
Affiliations
- PMID: 14704747
- DOI: 10.1038/sj.ijo.0802503
Item in Clipboard
Review
Role of Ser/Thr kinases in the uncoupling of insulin signaling
Int J Obes Relat Metab Disord.
2003 Dec.
Abstract
Insulin resistance refers to a decreased capacity of circulating insulin to regulate nutrient metabolism. It is associated with the development of type II diabetes, a 21st century epidemic. Recent studies reveal that agents that induce insulin resistance exploit phosphorylation-based negative feedback control mechanisms otherwise utilized by insulin itself, to uncouple the insulin receptor from its downstream effectors and thereby terminate insulin signal transduction. This article focuses on the cardinal role of Ser/Thr protein kinases, which phosphorylate insulin receptor substrates, as key players in the uncoupling of insulin signaling and the induction of an insulin resistance state.
Similar articles
-
Uncoupling insulin signalling by serine/threonine phosphorylation: a molecular basis for insulin resistance.Biochem Soc Trans. 2004 Nov;32(Pt 5):812-6. doi: 10.1042/BST0320812. Biochem Soc Trans. 2004. PMID: 15494022 Review.
-
Insulin resistance: a phosphorylation-based uncoupling of insulin signaling.Trends Cell Biol. 2001 Nov;11(11):437-41. doi: 10.1016/s0962-8924(01)02129-8. Trends Cell Biol. 2001. PMID: 11684411
-
Phosphorylation of IRS proteins, insulin action, and insulin resistance.Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E581-91. doi: 10.1152/ajpendo.90437.2008. Epub 2008 Aug 26. Am J Physiol Endocrinol Metab. 2009. PMID: 18728222 Review.
-
Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin resistance.Sci STKE. 2005 Jan 25;2005(268):pe4. doi: 10.1126/stke.2682005pe4. Sci STKE. 2005. PMID: 15671481 Review.
-
Akt mediates the cross-talk between beta-adrenergic and insulin receptors in neonatal cardiomyocytes.Circ Res. 2005 Feb 4;96(2):180-8. doi: 10.1161/01.RES.0000152968.71868.c3. Epub 2004 Dec 9. Circ Res. 2005. PMID: 15591229
Cited by
-
The blockade of the TGF-β pathway alleviates abnormal glucose and lipid metabolism of lipodystrophy not obesity.Pharmacol Res Perspect. 2024 Feb;12(1):e1160. doi: 10.1002/prp2.1160. Pharmacol Res Perspect. 2024. PMID: 38174807 Free PMC article.
-
Increased skeletal muscle tumor necrosis factor-alpha and impaired insulin signaling persist in obese women with gestational diabetes mellitus 1 year postpartum.Diabetes. 2008 Mar;57(3):606-13. doi: 10.2337/db07-1356. Epub 2007 Dec 14. Diabetes. 2008. PMID: 18083784 Free PMC article.
-
Obesity and colorectal cancer: role of adipokines in tumor initiation and progression.World J Gastroenterol. 2014 May 14;20(18):5177-90. doi: 10.3748/wjg.v20.i18.5177. World J Gastroenterol. 2014. PMID: 24833848 Free PMC article. Review.
-
Modulation of glucose transporter protein by dietary flavonoids in type 2 diabetes mellitus.Int J Biol Sci. 2015 Mar 19;11(5):508-24. doi: 10.7150/ijbs.11241. eCollection 2015. Int J Biol Sci. 2015. PMID: 25892959 Free PMC article. Review.
-
Palmitate-activated macrophages confer insulin resistance to muscle cells by a mechanism involving protein kinase C θ and ε.PLoS One. 2011;6(10):e26947. doi: 10.1371/journal.pone.0026947. Epub 2011 Oct 26. PLoS One. 2011. PMID: 22046423 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources