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. 2003 Nov;12(11 Pt 1):1253-6.

Urinary mutagenicity and colorectal adenoma risk

Ulrike Peters  1 , David M DeMarini, Rashmi Sinha, Lance R Brooks, Sarah H Warren, Nilanjan Chatterjee, Nathaniel Rothman
Affiliations
  • PMID: 14652290

Urinary mutagenicity and colorectal adenoma risk

Ulrike Peters et al. Cancer Epidemiol Biomarkers Prev. 2003 Nov.

Abstract

We investigated urinary mutagenicity and colorectal adenoma risk in a clinic-based, case-control study of currently nonsmoking cases (n = 143) and controls (n = 156). Urinary organics were extracted by C18/methanol from 12-h overnight urine samples, and mutagenicity was determined in Salmonella YG1024 +S9 (Ames test). Adenoma risk was 2.4-fold higher in subjects in the highest versus the lowest quintile of urinary mutagenicity (95% confidence interval = 1.1-5.1). Combining urinary mutagenicity with intake of meat-derived mutagenicity (from our earlier analysis) resulted in a 5.6-fold increase in adenoma risk (95% confidence interval = 2.2-13.9, comparing the highest with the lowest quintile). In our study population, diet may have contributed to mutagenic exposure, which was positively associated with colorectal adenoma risk.

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