Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Nov;84(Pt 11):3115-3120.
doi: 10.1099/vir.0.19357-0.

Major changes in the G protein of human respiratory syncytial virus isolates introduced by a duplication of 60 nucleotides

Alfonsina Trento  1   2 , Mónica Galiano  1 , Cristina Videla  1 , Guadalupe Carballal  1 , Blanca García-Barreno  2 , José A Melero  2 , Concepción Palomo  2
Affiliations

Major changes in the G protein of human respiratory syncytial virus isolates introduced by a duplication of 60 nucleotides

Alfonsina Trento et al. J Gen Virol. 2003 Nov.

Abstract

The entire nucleotide sequence of the G gene of three human respiratory syncytial virus (HRSV) isolates (antigenic group B) has been determined. These three viruses (named BA viruses) were isolated in Buenos Aires in 1999 from specimens collected in different hospitals and at different dates. BA viruses have an exact duplication of 60 nucleotides in the G gene, starting after residue 791. This duplication is flanked by a repeat of four nucleotides (GUGU) and can fold into a relatively stable secondary structure. These features suggest a possible mechanism for the generation of a duplicated G segment. The predicted polypeptide is lengthened by 20 amino acids (residues 260-279) and this is reflected in the slower electrophoretic mobility of the G protein precursor of BA viruses compared with related viruses. The changes reported here expand the examples of drastic genetic alterations that can be introduced into the G protein sequence of HRSV while it replicates in its natural host.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

LinkOut - more resources