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doi: 10.1016/s0092-8674(03)00804-3.
The double life of ribosomal proteins
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- PMID: 14567909
- DOI: 10.1016/s0092-8674(03)00804-3
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The double life of ribosomal proteins
Cell.
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Abstract
Many integral proteins of the ribosome also carry out extra-ribosomal functions as independent polypeptides, raising questions as to their evolutionary derivation. In this issue of Cell, Mazumder et al. report a surprising new twist in the dual life of these molecules: as part of a cellular response to interferon, a large-subunit protein dramatically exits the ribosome to bind and inhibit the translation of a specific mRNA.
Comment on
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Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control.Cell. 2003 Oct 17;115(2):187-98. doi: 10.1016/s0092-8674(03)00773-6. Cell. 2003. PMID: 14567916
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