Review
doi: 10.1038/nrm1198.
Titin: properties and family relationships
Affiliations
- PMID: 14506471
- DOI: 10.1038/nrm1198
Item in Clipboard
Review
Titin: properties and family relationships
Nat Rev Mol Cell Biol.
2003 Sep.
Abstract
In striated muscles, the rapid production of macroscopic levels of force and displacement stems directly from highly ordered and hierarchical protein organization, with the sarcomere as the elemental contractile unit. There is now a wealth of evidence indicating that the giant elastic protein titin has important roles in controlling the structure and extensibility of vertebrate muscle sarcomeres.
Similar articles
-
Role of titin in vertebrate striated muscle.Philos Trans R Soc Lond B Biol Sci. 2002 Feb 28;357(1418):199-206. doi: 10.1098/rstb.2001.1028. Philos Trans R Soc Lond B Biol Sci. 2002. PMID: 11911777 Free PMC article. Review.
-
Reverse engineering of the giant muscle protein titin.Nature. 2002 Aug 29;418(6901):998-1002. doi: 10.1038/nature00938. Nature. 2002. PMID: 12198551
-
PEVK domain of titin: an entropic spring with actin-binding properties.J Struct Biol. 2002 Jan-Feb;137(1-2):194-205. doi: 10.1006/jsbi.2002.4468. J Struct Biol. 2002. PMID: 12064946
-
Evidence for the oligomeric state of 'elastic' titin in muscle sarcomeres.J Mol Biol. 2008 Dec 12;384(2):299-312. doi: 10.1016/j.jmb.2008.09.030. Epub 2008 Sep 20. J Mol Biol. 2008. PMID: 18824175
-
Structure-function relations of the giant elastic protein titin in striated and smooth muscle cells.Muscle Nerve. 2007 Dec;36(6):740-55. doi: 10.1002/mus.20886. Muscle Nerve. 2007. PMID: 17763461 Review.
Cited by
-
Engineering of an elastic scaffolding polyprotein based on an SH3-binding intrinsically disordered titin PEVK module.Protein Expr Purif. 2012 Oct;85(2):187-99. doi: 10.1016/j.pep.2012.08.003. Epub 2012 Aug 14. Protein Expr Purif. 2012. PMID: 22910563 Free PMC article.
-
Analysis of tarantula skeletal muscle protein sequences and identification of transcriptional isoforms.BMC Genomics. 2009 Mar 19;10:117. doi: 10.1186/1471-2164-10-117. BMC Genomics. 2009. PMID: 19298669 Free PMC article.
-
The Src homology and collagen A (ShcA) adaptor protein is required for the spatial organization of the costamere/Z-disk network during heart development.J Biol Chem. 2015 Jan 23;290(4):2419-30. doi: 10.1074/jbc.M114.597377. Epub 2014 Dec 8. J Biol Chem. 2015. PMID: 25488665 Free PMC article.
-
Comprehensive analysis of titin protein isoform and alternative splicing in normal and mutant rats.J Cell Biochem. 2012 Apr;113(4):1265-73. doi: 10.1002/jcb.23459. J Cell Biochem. 2012. PMID: 22105831 Free PMC article.
-
Mechanotransduction in cardiac hypertrophy and failure.Circ Res. 2015 Apr 10;116(8):1462-1476. doi: 10.1161/CIRCRESAHA.116.304937. Circ Res. 2015. PMID: 25858069 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
