Adenosine A3 receptors are located in neurons of the rat hippocampus
- PMID: 14502093
- DOI: 10.1097/00001756-200308260-00021
Adenosine A3 receptors are located in neurons of the rat hippocampus
Abstract
Adenosine is a neuromodulator acting mainly via inhibitory A1 and facilitatory A2A receptors. Whole tissue PCR also identified adenosine A3 receptors in the brain and A3 receptor agonists affect CNS neuronal responses and viability. However, recent reports failed to detect A3 receptor expression in CNS neurons and showed that A3 receptor agonists can bind and activate A1 receptors. We now present evidence for the presence of A3 receptor mRNA in CNS neurons using single cell PCR analysis of laser dissected hippocampal neurons. Western blot analysis showed that A3 receptors are present in rat hippocampal nerve terminal membranes. This indicates that A3 receptors are present in CNS neurons in the hippocampus.
Similar articles
-
Stimulation of the adenosine A3 receptor, not the A1 or A2 receptors, promote neurite outgrowth of retinal ganglion cells.Exp Eye Res. 2018 May;170:160-168. doi: 10.1016/j.exer.2018.02.019. Epub 2018 Feb 24. Exp Eye Res. 2018. PMID: 29486164
-
Adenosine A1 and A2A receptors are co-expressed in pyramidal neurons and co-localized in glutamatergic nerve terminals of the rat hippocampus.Neuroscience. 2005;133(1):79-83. doi: 10.1016/j.neuroscience.2005.01.054. Neuroscience. 2005. PMID: 15893632
-
Retinal A2A and A3 adenosine receptors modulate the components of the rat electroretinogram.Vis Neurosci. 2017 Jan;34:E001. doi: 10.1017/S0952523816000171. Vis Neurosci. 2017. PMID: 28304243
-
From A1 to A3 en passant through A(2A) receptors in the hippocampus: pharmacological implications.CNS Neurol Disord Drug Targets. 2012 Sep;11(6):652-63. doi: 10.2174/187152712803581074. CNS Neurol Disord Drug Targets. 2012. PMID: 22963437 Review.
-
[Neuroprotective mechanisms of adenosine action on CNS neurons].Neurol Neurochir Pol. 2002 Mar-Apr;36(2):329-36. Neurol Neurochir Pol. 2002. PMID: 12046508 Review. Polish.
Cited by
-
Enhanced neurodegeneration after a high dose of methamphetamine in adenosine A3 receptor null mutant mice.Neuroscience. 2011 Oct 27;194:170-80. doi: 10.1016/j.neuroscience.2011.08.013. Epub 2011 Aug 10. Neuroscience. 2011. PMID: 21867746 Free PMC article.
-
Neuroprotection by adenosine in the brain: From A(1) receptor activation to A (2A) receptor blockade.Purinergic Signal. 2005 Jun;1(2):111-34. doi: 10.1007/s11302-005-0649-1. Epub 2005 Mar 17. Purinergic Signal. 2005. PMID: 18404497 Free PMC article.
-
Role of nitric oxide in the behavioral and neurochemical effects of IB-MECA in zebrafish.Psychopharmacology (Berl). 2015 May;232(10):1671-80. doi: 10.1007/s00213-014-3799-4. Epub 2014 Nov 13. Psychopharmacology (Berl). 2015. PMID: 25388291
-
Adverse and protective influences of adenosine on the newborn and embryo: implications for preterm white matter injury and embryo protection.Pediatr Res. 2011 Apr;69(4):271-8. doi: 10.1203/PDR.0b013e31820efbcf. Pediatr Res. 2011. PMID: 21228731 Free PMC article. Review.
-
Elevated Pressure Changes the Purinergic System of Microglial Cells.Front Pharmacol. 2018 Jan 24;9:16. doi: 10.3389/fphar.2018.00016. eCollection 2018. Front Pharmacol. 2018. PMID: 29416510 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases