doi: 10.1097/00001756-200308260-00021.
Adenosine A3 receptors are located in neurons of the rat hippocampus
Affiliations
- PMID: 14502093
- DOI: 10.1097/00001756-200308260-00021
Item in Clipboard
Adenosine A3 receptors are located in neurons of the rat hippocampus
Neuroreport.
.
Abstract
Adenosine is a neuromodulator acting mainly via inhibitory A1 and facilitatory A2A receptors. Whole tissue PCR also identified adenosine A3 receptors in the brain and A3 receptor agonists affect CNS neuronal responses and viability. However, recent reports failed to detect A3 receptor expression in CNS neurons and showed that A3 receptor agonists can bind and activate A1 receptors. We now present evidence for the presence of A3 receptor mRNA in CNS neurons using single cell PCR analysis of laser dissected hippocampal neurons. Western blot analysis showed that A3 receptors are present in rat hippocampal nerve terminal membranes. This indicates that A3 receptors are present in CNS neurons in the hippocampus.
Similar articles
-
Stimulation of the adenosine A3 receptor, not the A1 or A2 receptors, promote neurite outgrowth of retinal ganglion cells.Exp Eye Res. 2018 May;170:160-168. doi: 10.1016/j.exer.2018.02.019. Epub 2018 Feb 24. Exp Eye Res. 2018. PMID: 29486164
-
Adenosine A1 and A2A receptors are co-expressed in pyramidal neurons and co-localized in glutamatergic nerve terminals of the rat hippocampus.Neuroscience. 2005;133(1):79-83. doi: 10.1016/j.neuroscience.2005.01.054. Neuroscience. 2005. PMID: 15893632
-
Retinal A2A and A3 adenosine receptors modulate the components of the rat electroretinogram.Vis Neurosci. 2017 Jan;34:E001. doi: 10.1017/S0952523816000171. Vis Neurosci. 2017. PMID: 28304243
-
From A1 to A3 en passant through A(2A) receptors in the hippocampus: pharmacological implications.CNS Neurol Disord Drug Targets. 2012 Sep;11(6):652-63. doi: 10.2174/187152712803581074. CNS Neurol Disord Drug Targets. 2012. PMID: 22963437 Review.
-
[Neuroprotective mechanisms of adenosine action on CNS neurons].Neurol Neurochir Pol. 2002 Mar-Apr;36(2):329-36. Neurol Neurochir Pol. 2002. PMID: 12046508 Review. Polish.
Cited by
-
G-Protein-Coupled Receptors and Ischemic Stroke: a Focus on Molecular Function and Therapeutic Potential.Mol Neurobiol. 2021 Sep;58(9):4588-4614. doi: 10.1007/s12035-021-02435-5. Epub 2021 Jun 12. Mol Neurobiol. 2021. PMID: 34120294 Review.
-
Electroacupuncture Relieves Neuropathic Pain via Adenosine 3 Receptor Activation in the Spinal Cord Dorsal Horn of Mice.Int J Mol Sci. 2024 Sep 24;25(19):10242. doi: 10.3390/ijms251910242. Int J Mol Sci. 2024. PMID: 39408573 Free PMC article.
-
A3 adenosine receptor activation mechanisms: molecular dynamics analysis of inactive, active, and fully active states.J Comput Aided Mol Des. 2019 Nov;33(11):983-996. doi: 10.1007/s10822-019-00246-4. Epub 2019 Nov 22. J Comput Aided Mol Des. 2019. PMID: 31758354 Free PMC article.
-
Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway.J Neurosci. 2009 Nov 25;29(47):14741-51. doi: 10.1523/JNEUROSCI.3728-09.2009. J Neurosci. 2009. PMID: 19940169 Free PMC article.
-
The Histamine H4 Receptor Participates in the Anti-Neuropathic Effect of the Adenosine A3 Receptor Agonist IB-MECA: Role of CD4+ T Cells.Biomolecules. 2021 Oct 2;11(10):1447. doi: 10.3390/biom11101447. Biomolecules. 2021. PMID: 34680083 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
