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. 1992 Nov;11(11):3921-6.
doi: 10.1002/j.1460-2075.1992.tb05485.x.

Crystal structure of human platelet-derived growth factor BB

C Oefner  1 , A D'Arcy, F K Winkler, B Eggimann, M Hosang
Affiliations

Crystal structure of human platelet-derived growth factor BB

C Oefner et al. EMBO J. 1992 Nov.

Abstract

The crystal structure of the homodimeric BB isoform of human recombinant platelet-derived growth factor (PDGF-BB) has been determined by X-ray analysis to 3.0 A resolution. The polypeptide chain is folded into two highly twisted antiparallel pairs of beta-strands and contains an unusual knotted arrangement of three intramolecular disulfide bonds. Dimerization leads to the clustering of three surface loops at each end of the elongated dimer, which most probably form the receptor recognition sites.

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References

    1. Trends Genet. 1989 Apr;5(4):108-11 - PubMed
    1. Cell. 1986 Jul 18;46(2):155-69 - PubMed
    1. Science. 1987 Jun 5;236(4806):1315-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1974 Apr;71(4):1207-10 - PubMed
    1. Exp Cell Res. 1974 Aug;87(2):297-301 - PubMed