doi: 10.1126/science.1352912.
Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones
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- PMID: 1352912
- DOI: 10.1126/science.1352912
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Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones
Science.
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Abstract
The adoptive transfer of antigen-specific T cells to establish immunity is an effective therapy for viral infections and tumors in animal models. The application of this approach to human disease would require the isolation and in vitro expansion of human antigen-specific T cells and evidence that such T cells persist and function in vivo after transfer. Cytomegalovirus-specific CD8+ cytotoxic T cell (CTL) clones could be isolated from bone marrow donors, propagated in vitro, and adoptively transferred to immunodeficient bone marrow transplant recipients. No toxicity developed and the clones provided persistent reconstitution of CD8+ cytomegalovirus-specific CTL responses.
Comment in
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Transferred immune cells may help fight viral infection.Science. 1992 Jul 10;257(5067):166. doi: 10.1126/science.1321492. Science. 1992. PMID: 1321492 No abstract available.
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