doi: 10.1038/359505a0.
Crystal structure at 1.7 A of the bovine papillomavirus-1 E2 DNA-binding domain bound to its DNA target
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- PMID: 1328886
- DOI: 10.1038/359505a0
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Crystal structure at 1.7 A of the bovine papillomavirus-1 E2 DNA-binding domain bound to its DNA target
Nature.
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Abstract
The dominant transcriptional regulator of the papillomaviruses, E2, binds to its specific DNA target through a previously unobserved dimeric antiparallel beta-barrel. The DNA is severely but smoothly bent over the barrel by the interaction of successive major grooves with a pair of symmetrically disposed alpha-helices. The specific interface is an 'interwoven' network of interactions where the identifying base pairs of the target contact more than one amino-acid side chain and the discriminating amino acids interact with more than one base pair.
Comment in
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Transcription factors. DNA recognition, warts and all.Nature. 1992 Oct 8;359(6395):476. doi: 10.1038/359476a0. Nature. 1992. PMID: 1328885 No abstract available.
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