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. 1992 Apr;66(4):1985-94.
doi: 10.1128/JVI.66.4.1985-1994.1992.

Inhibition of poliovirus RNA synthesis by brefeldin A

L A Maynell  1 , K Kirkegaard, M W Klymkowsky
Affiliations

Inhibition of poliovirus RNA synthesis by brefeldin A

L A Maynell et al. J Virol. 1992 Apr.

Abstract

Brefeldin A (BFA), a fungal metabolite that blocks transport of newly synthesized proteins from the endoplasmic reticulum, was found to inhibit poliovirus replication 10(5)- to 10(6)-fold. BFA does not inhibit entry of poliovirus into the cell or translation of viral RNA. Poliovirus RNA synthesis, however, is completely inhibited by BFA. A specific class of membranous vesicles, with which the poliovirus replication complex is physically associated, is known to proliferate in poliovirus-infected cells. BFA may inhibit poliovirus replication by preventing the formation of these vesicles.

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