Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Dec;2(4):330-4.
doi: 10.1038/ng1292-330.

Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14

P St George-Hyslop  1 , J Haines, E Rogaev, M Mortilla, G Vaula, M Pericak-Vance, J F Foncin, M Montesi, A Bruni, S Sorbi, I Rainero, L Pinessi, D Pollen, R Polinsky, L Nee, J Kennedy, F Macciardi, E Rogaeva, Y Liang, N Alexandrova, W Lukiw, K Schlumpf, R Tanzi, T Tsuda, L Farrer, J M Cantu, R Duara, L Amaducci, L Bergamini, J Gusella, A Roses, D Crapper McLachlan, et al.
Affiliations
Free article

Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14

P St George-Hyslop et al. Nat Genet. 1992 Dec.
Free article

Abstract

Familial Alzheimer's disease (FAD) has been shown to be genetically heterogeneous, with a very small proportion of early onset pedigrees being associated with mutations in the amyloid precursor protein (APP) gene on chromosome 21, and some late onset pedigrees showing associations with markers on chromosome 19. We now provide evidence for a major early onset FAD locus on the long arm of chromosome 14 near the markers D14S43 and D14S53 (multipoint lod score z = 23.4) and suggest that the inheritance of FAD may be more complex than had initially been suspected.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

LinkOut - more resources