Expression of FGF receptors 1, 2, 3 in the embryonic and postnatal mouse brain compared with Pdgfralpha, Olig2 and Plp/dm20: implications for oligodendrocyte development
- PMID: 12966207
- DOI: 10.1159/000072258
Expression of FGF receptors 1, 2, 3 in the embryonic and postnatal mouse brain compared with Pdgfralpha, Olig2 and Plp/dm20: implications for oligodendrocyte development
Abstract
Fibroblast growth factors (FGF) receptors FgfR1, FgfR2 and FgfR3 are differentially regulated during oligodendrocyte (OL) maturation in vitro: FgfR3 is expressed by OL progenitors whereas FgfR2 is expressed by differentiated OLs [Mol Cell Neurosci 1996;7:263-275], and we have recently shown that FgfR3 is required for the timely differentiation of OLs in vivo [J Neurosci 2003;23:883-894]. Here we have used in situ hybridization to investigate the expression patterns of FgfR1-3 and compare them to the putative OL progenitor markers Olig2, Pdgfralpha and Plp/dm20 as a function of development in vivo, in particular at sites of OL specification, migration or differentiation in the mouse forebrain and cerebellum. We show that at early stages FgfR1-3 expression overlaps with that of Olig2 in the embryonic ventricular zone of the lateral and medial ganglionic eminences. Further, a scattered population of cells expressing FgfR3 (but not FgfR1 or FgfR2) in the ventral telencephalon appear to arise from the ventricular zone, and at later stages are found more dorsally in the cortex, in an overall pattern similar to Olig2 and/or Pdgfralpha. Postnatal expression of FgfR2 increases with age, more prominently in specific regions, including the cortical and cerebellar white matter and optic nerve. Thus, the differential expression pattern of FgfR2 and FgfR3 observed in vivo suggests that their expression is developmentally regulated in a manner consistent with the pattern of their expression in culture. These data provide further insights into role of FgfRs in OL development, and they emphasize that these receptors are positioned both spatially and temporally to impact OL generation in vivo.
Copyright 2003 S. Karger AG, Basel
Similar articles
-
Evidence for a second wave of oligodendrogenesis in the postnatal cerebral cortex of the mouse.J Neurosci Res. 2003 Sep 1;73(5):581-92. doi: 10.1002/jnr.10717. J Neurosci Res. 2003. PMID: 12929126
-
Sonic hedgehog contributes to oligodendrocyte specification in the mammalian forebrain.Development. 2001 Feb;128(4):527-40. doi: 10.1242/dev.128.4.527. Development. 2001. PMID: 11171336
-
Olig2/Plp-positive progenitor cells give rise to Bergmann glia in the cerebellum.Cell Death Dis. 2013 Mar 14;4(3):e546. doi: 10.1038/cddis.2013.74. Cell Death Dis. 2013. PMID: 23492777 Free PMC article.
-
Single or multiple oligodendroglial lineages: a controversy.Glia. 2000 Jan 15;29(2):143-8. Glia. 2000. PMID: 10625332 Review.
-
The early steps of oligodendrogenesis: insights from the study of the plp lineage in the brain of chicks and rodents.Dev Neurosci. 2001;23(4-5):318-26. doi: 10.1159/000048715. Dev Neurosci. 2001. PMID: 11756747 Review.
Cited by
-
Learning and memory depend on fibroblast growth factor receptor 2 functioning in hippocampus.Biol Psychiatry. 2012 Jun 15;71(12):1090-8. doi: 10.1016/j.biopsych.2012.03.013. Epub 2012 Apr 27. Biol Psychiatry. 2012. PMID: 22541947 Free PMC article.
-
The insulin-like growth factor (IGF) receptor type 1 (IGF1R) as an essential component of the signalling network regulating neurogenesis.Mol Neurobiol. 2009 Dec;40(3):195-215. doi: 10.1007/s12035-009-8081-0. Epub 2009 Aug 29. Mol Neurobiol. 2009. PMID: 19714501 Review.
-
Disruption of the Suprachiasmatic Nucleus in Fibroblast Growth Factor Signaling-Deficient Mice.Front Endocrinol (Lausanne). 2016 Feb 8;7:11. doi: 10.3389/fendo.2016.00011. eCollection 2016. Front Endocrinol (Lausanne). 2016. PMID: 26903947 Free PMC article.
-
FRS2α regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells.Stem Cells. 2010 Sep;28(9):1661-73. doi: 10.1002/stem.488. Stem Cells. 2010. PMID: 20652960 Free PMC article.
-
Midface and upper airway dysgenesis in FGFR2-related craniosynostosis involves multiple tissue-specific and cell cycle effects.Development. 2018 Oct 5;145(19):dev166488. doi: 10.1242/dev.166488. Development. 2018. PMID: 30228104 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Research Materials
Miscellaneous