Expression of FGF receptors 1, 2, 3 in the embryonic and postnatal mouse brain compared with Pdgfralpha, Olig2 and Plp/dm20: implications for oligodendrocyte development
- PMID: 12966207
- DOI: 10.1159/000072258
Expression of FGF receptors 1, 2, 3 in the embryonic and postnatal mouse brain compared with Pdgfralpha, Olig2 and Plp/dm20: implications for oligodendrocyte development
Abstract
Fibroblast growth factors (FGF) receptors FgfR1, FgfR2 and FgfR3 are differentially regulated during oligodendrocyte (OL) maturation in vitro: FgfR3 is expressed by OL progenitors whereas FgfR2 is expressed by differentiated OLs [Mol Cell Neurosci 1996;7:263-275], and we have recently shown that FgfR3 is required for the timely differentiation of OLs in vivo [J Neurosci 2003;23:883-894]. Here we have used in situ hybridization to investigate the expression patterns of FgfR1-3 and compare them to the putative OL progenitor markers Olig2, Pdgfralpha and Plp/dm20 as a function of development in vivo, in particular at sites of OL specification, migration or differentiation in the mouse forebrain and cerebellum. We show that at early stages FgfR1-3 expression overlaps with that of Olig2 in the embryonic ventricular zone of the lateral and medial ganglionic eminences. Further, a scattered population of cells expressing FgfR3 (but not FgfR1 or FgfR2) in the ventral telencephalon appear to arise from the ventricular zone, and at later stages are found more dorsally in the cortex, in an overall pattern similar to Olig2 and/or Pdgfralpha. Postnatal expression of FgfR2 increases with age, more prominently in specific regions, including the cortical and cerebellar white matter and optic nerve. Thus, the differential expression pattern of FgfR2 and FgfR3 observed in vivo suggests that their expression is developmentally regulated in a manner consistent with the pattern of their expression in culture. These data provide further insights into role of FgfRs in OL development, and they emphasize that these receptors are positioned both spatially and temporally to impact OL generation in vivo.
Copyright 2003 S. Karger AG, Basel
Similar articles
-
Evidence for a second wave of oligodendrogenesis in the postnatal cerebral cortex of the mouse.J Neurosci Res. 2003 Sep 1;73(5):581-92. doi: 10.1002/jnr.10717. J Neurosci Res. 2003. PMID: 12929126
-
Sonic hedgehog contributes to oligodendrocyte specification in the mammalian forebrain.Development. 2001 Feb;128(4):527-40. doi: 10.1242/dev.128.4.527. Development. 2001. PMID: 11171336
-
Olig2/Plp-positive progenitor cells give rise to Bergmann glia in the cerebellum.Cell Death Dis. 2013 Mar 14;4(3):e546. doi: 10.1038/cddis.2013.74. Cell Death Dis. 2013. PMID: 23492777 Free PMC article.
-
Single or multiple oligodendroglial lineages: a controversy.Glia. 2000 Jan 15;29(2):143-8. Glia. 2000. PMID: 10625332 Review.
-
The early steps of oligodendrogenesis: insights from the study of the plp lineage in the brain of chicks and rodents.Dev Neurosci. 2001;23(4-5):318-26. doi: 10.1159/000048715. Dev Neurosci. 2001. PMID: 11756747 Review.
Cited by
-
Brain phenotypes in two FGFR2 mouse models for Apert syndrome.Dev Dyn. 2010 Mar;239(3):987-97. doi: 10.1002/dvdy.22218. Dev Dyn. 2010. PMID: 20077479 Free PMC article.
-
Fibroblast Growth Factors in Depression.Front Pharmacol. 2019 Feb 5;10:60. doi: 10.3389/fphar.2019.00060. eCollection 2019. Front Pharmacol. 2019. PMID: 30804785 Free PMC article. Review.
-
FGF signaling controls Shh-dependent oligodendroglial fate specification in the ventral spinal cord.Neural Dev. 2018 Mar 8;13(1):3. doi: 10.1186/s13064-018-0100-2. Neural Dev. 2018. PMID: 29519242 Free PMC article.
-
Receptor tyrosine kinase (RTK) signalling in the control of neural stem and progenitor cell (NSPC) development.Mol Neurobiol. 2014 Feb;49(1):440-71. doi: 10.1007/s12035-013-8532-5. Epub 2013 Aug 28. Mol Neurobiol. 2014. PMID: 23982746 Review.
-
Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned.Front Cell Neurosci. 2014 Mar 13;8:73. doi: 10.3389/fncel.2014.00073. eCollection 2014. Front Cell Neurosci. 2014. PMID: 24659953 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Research Materials
Miscellaneous