Sleep states alter activity of suprachiasmatic nucleus neurons
- PMID: 12958601
- DOI: 10.1038/nn1122
Sleep states alter activity of suprachiasmatic nucleus neurons
Abstract
The timing of sleep and wakefulness in mammals is governed by a sleep homeostatic process and by the circadian clock of the suprachiasmatic nucleus (SCN), which has a molecular basis for rhythm generation. By combining SCN electrical activity recordings with electroencephalogram (EEG) recordings in the same animal (the Wistar rat), we discovered that changes in vigilance states are paralleled by strong changes in SCN electrophysiological activity. During rapid eye movement (REM) sleep, neuronal activity in the SCN was elevated, and during non-REM (NREM) sleep, it was lowered. We also carried out selective sleep deprivation experiments to confirm that changes in SCN electrical activity are caused by changes in vigilance state. Our results indicate that the 24-hour pattern in electrical activity that is controlled by the molecular machinery of the SCN is substantially modified by afferent information from the central nervous system.
Comment in
-
Sleep and circadian rhythms: do sleep centers talk back to the clock?Nat Neurosci. 2003 Oct;6(10):1005-6. doi: 10.1038/nn1003-1005. Nat Neurosci. 2003. PMID: 14513032 Free PMC article. Review.
Similar articles
-
[Circadian oscillator in the suprachiasmatic nucleus: systemic electrophysiologic studies].Wien Med Wochenschr. 1995;145(17-18):390-2. Wien Med Wochenschr. 1995. PMID: 8588350 German.
-
Long term effects of sleep deprivation on the mammalian circadian pacemaker.Sleep. 2007 Mar;30(3):257-62. doi: 10.1093/sleep/30.3.257. Sleep. 2007. PMID: 17425221
-
Circadian regulation of sleep in mammals: role of the suprachiasmatic nucleus.Brain Res Brain Res Rev. 2005 Nov;49(3):429-54. doi: 10.1016/j.brainresrev.2005.01.005. Brain Res Brain Res Rev. 2005. PMID: 16269313 Review.
-
The suprachiasmatic nucleus regulates sleep timing and amount in mice.Sleep. 2004 Nov 1;27(7):1307-18. doi: 10.1093/sleep/27.7.1307. Sleep. 2004. PMID: 15586783
-
Processing of daily and seasonal light information in the mammalian circadian clock.Gen Comp Endocrinol. 2007 Jun-Jul;152(2-3):159-64. doi: 10.1016/j.ygcen.2007.01.018. Epub 2007 Jan 25. Gen Comp Endocrinol. 2007. PMID: 17324426 Review.
Cited by
-
Jet lag syndrome: circadian organization, pathophysiology, and management strategies.Nat Sci Sleep. 2010 Aug 19;2:187-98. doi: 10.2147/NSS.S6683. Print 2010. Nat Sci Sleep. 2010. PMID: 23616709 Free PMC article.
-
Voluntary exercise can strengthen the circadian system in aged mice.Age (Dordr). 2013 Dec;35(6):2137-52. doi: 10.1007/s11357-012-9502-y. Epub 2013 Jan 23. Age (Dordr). 2013. PMID: 23340916 Free PMC article.
-
Chronic sleep loss disrupts rhythmic gene expression in Drosophila.Front Physiol. 2022 Nov 18;13:1048751. doi: 10.3389/fphys.2022.1048751. eCollection 2022. Front Physiol. 2022. PMID: 36467698 Free PMC article.
-
BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis.PLoS Biol. 2004 Nov;2(11):e377. doi: 10.1371/journal.pbio.0020377. Epub 2004 Nov 2. PLoS Biol. 2004. PMID: 15523558 Free PMC article.
-
Phospholipase C-beta4 is essential for the progression of the normal sleep sequence and ultradian body temperature rhythms in mice.PLoS One. 2009 Nov 9;4(11):e7737. doi: 10.1371/journal.pone.0007737. PLoS One. 2009. PMID: 19898623 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
