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Comparative Study
. 2003 Oct 10;302(5643):276-8.
doi: 10.1126/science.1087139. Epub 2003 Sep 4.

Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China

Y Guan  1 , B J Zheng, Y Q He, X L Liu, Z X Zhuang, C L Cheung, S W Luo, P H Li, L J Zhang, Y J Guan, K M Butt, K L Wong, K W Chan, W Lim, K F Shortridge, K Y Yuen, J S M Peiris, L L M Poon
Affiliations
Comparative Study

Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China

Y Guan et al. Science. .

Abstract

A novel coronavirus (SCoV) is the etiological agent of severe acute respiratory syndrome (SARS). SCoV-like viruses were isolated from Himalayan palm civets found in a live-animal market in Guangdong, China. Evidence of virus infection was also detected in other animals (including a raccoon dog, Nyctereutes procyonoides) and in humans working at the same market. All the animal isolates retain a 29-nucleotide sequence that is not found in most human isolates. The detection of SCoV-like viruses in small, live wild mammals in a retail market indicates a route of interspecies transmission, although the natural reservoir is not known.

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