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Comparative Study
. 2003 Aug 15;260(2):404-13.
doi: 10.1016/s0012-1606(03)00256-2.

Molecular signature of human embryonic stem cells and its comparison with the mouse

Noboru Sato  1 , Ignacio Munoz Sanjuan, Michael Heke, Makiko Uchida, Felix Naef, Ali H Brivanlou
Affiliations
Free article
Comparative Study

Molecular signature of human embryonic stem cells and its comparison with the mouse

Noboru Sato et al. Dev Biol. .
Free article

Abstract

The molecular mechanism underlying pluripotency is largely unknown. Here, we provide the first global transcriptional profile of the state of "stemness" in human embryonic stem cells (HESCs). We have identified a set of 918 genes enriched in undifferentiated HESCs compared with their differentiated counterparts. These include ligand/receptor pairs and secreted inhibitors of the FGF, TGFbeta/BMP, and Wnt pathways, highlighting a prevalent role for these pathways in HESCs. Importantly, a significant number of HESCs-enriched genes, including several signaling components, are found to be intersected with published mouse embryonic stem cell data, indicating that a "core molecular program" is shared between the two pluripotent stem cells.

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