Review
doi: 10.1016/s1097-2765(03)00284-3.
Inactivating chromosomes: a macro domain that minimizes transcription
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- PMID: 12887886
- DOI: 10.1016/s1097-2765(03)00284-3
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Review
Inactivating chromosomes: a macro domain that minimizes transcription
Mol Cell.
2003 Jul.
Free article
Abstract
The histone variant macroH2A plays a role in mammalian chromosome X inactivation. Recent data suggest its unusual C-terminal macro domain may be an enzyme that regulates the ADP-ribosylation of chromatin. MacroH2A could thus help correct gene dosage between males and females using a novel epigenetic mark.
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