Biodegradable microspheres for protein delivery
- PMID: 12880694
- DOI: 10.1016/s0168-3659(03)00194-9
Biodegradable microspheres for protein delivery
Abstract
In a very short time, since their emergence, the field of controlled delivery of proteins has grown immensely. Because of their relatively large size, they have low transdermal bioavailabilities. Oral bioavailability is generally poor since they are poorly absorbed and easily degraded by proteolytic enzymes in the gastrointestinal tract. Ocular and nasal delivery is also unfavorable due to degradation by enzymes present in eye tissues and nasal mucosa. Thus parenteral delivery is currently most demanding and suitable for delivery of such molecules. In systemic delivery of proteins, biodegradable microspheres as parenteral depot formulation occupy an important place because of several aspects like protection of sensitive proteins from degradation, prolonged or modified release, pulsatile release patterns. The main objective in developing controlled release protein injectables is avoidance of regular invasive doses which in turn provide patient compliance, comfort as well as control over blood levels. This review presents the outstanding contributions in field of biodegradable microspheres as protein delivery systems, their methods of preparation, drug release, stability, interaction with immune system and regulatory considerations.
Similar articles
-
Microencapsulation peptide and protein drugs delivery system.Colloids Surf B Biointerfaces. 2005 Mar 25;41(2-3):117-20. doi: 10.1016/j.colsurfb.2004.10.032. Epub 2005 Jan 1. Colloids Surf B Biointerfaces. 2005. PMID: 15737536
-
Biodegradable microspheres for parenteral delivery.Crit Rev Ther Drug Carrier Syst. 2005;22(6):535-602. doi: 10.1615/critrevtherdrugcarriersyst.v22.i6.20. Crit Rev Ther Drug Carrier Syst. 2005. PMID: 16566705 Review.
-
Recent advances in protein and peptide drug delivery systems.Curr Drug Deliv. 2007 Apr;4(2):141-51. doi: 10.2174/156720107780362339. Curr Drug Deliv. 2007. PMID: 17456033 Review.
-
Review Article: Fabricated Microparticles: An Innovative Method to Minimize the Side Effects of NSAIDs in Arthritis.Crit Rev Ther Drug Carrier Syst. 2016;33(5):433-488. doi: 10.1615/CritRevTherDrugCarrierSyst.2016016624. Crit Rev Ther Drug Carrier Syst. 2016. PMID: 27910742 Review.
-
Controlled delivery of peptides and proteins.Curr Pharm Des. 2007;13(1):99-117. doi: 10.2174/138161207779313795. Curr Pharm Des. 2007. PMID: 17266590 Review.
Cited by
-
3D printing of recombinant collagen/chitosan methacrylate/nanoclay hydrogels loaded with Kartogenin nanoparticles for cartilage regeneration.Regen Biomater. 2024 Aug 28;11:rbae097. doi: 10.1093/rb/rbae097. eCollection 2024. Regen Biomater. 2024. PMID: 39220741 Free PMC article.
-
Challenges and Therapeutic Approaches for the Protein Delivery System: A Review.Pharm Nanotechnol. 2024;12(5):391-411. doi: 10.2174/0122117385265979231115074255. Pharm Nanotechnol. 2024. PMID: 38192140 Review.
-
The Management of Parkinson's Disease: An Overview of the Current Advancements in Drug Delivery Systems.Pharmaceutics. 2023 May 15;15(5):1503. doi: 10.3390/pharmaceutics15051503. Pharmaceutics. 2023. PMID: 37242745 Free PMC article. Review.
-
Formulation and Evaluation of Pravastatin Sodium-Loaded PLGA Nanoparticles: In vitro-in vivo Studies Assessment.Int J Nanomedicine. 2023 Feb 13;18:721-742. doi: 10.2147/IJN.S394701. eCollection 2023. Int J Nanomedicine. 2023. PMID: 36816332 Free PMC article.
-
Nanoparticles and convergence of artificial intelligence for targeted drug delivery for cancer therapy: Current progress and challenges.Front Med Technol. 2023 Jan 6;4:1067144. doi: 10.3389/fmedt.2022.1067144. eCollection 2022. Front Med Technol. 2023. PMID: 36688144 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources