Review
doi: 10.1016/s1471-4922(03)00139-9.
Class and subclass selection in parasite-specific antibody responses
Affiliations
- PMID: 12855380
- DOI: 10.1016/s1471-4922(03)00139-9
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Review
Class and subclass selection in parasite-specific antibody responses
Trends Parasitol.
2003 Jul.
Abstract
Antibodies are characteristically induced in many parasitic infection processes. The class and subclass of the antibody response is instrumental because each isotype has a distinct biological function. It is thus crucially important for an infected individual to mount the most appropriate secondary antibody response--that is the response that has the best chance of clearing the infection and/or controlling disease. This represents a fundamental of vaccine strategies. Immuno-epidemiological surveys and in vitro models of antibody production have helped to understand some of the goals which should be achieved when designing antiparasitic vaccines.
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