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Review
. 2004 Feb;447(5):784-95.
doi: 10.1007/s00424-003-1117-9. Epub 2003 Jul 4.

Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family

Bryan Mackenzie  1 , Jeffrey D Erickson
Affiliations
Review

Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family

Bryan Mackenzie et al. Pflugers Arch. 2004 Feb.

Abstract

The sodium-coupled neutral amino acid transporters (SNAT) of the SLC38 gene family resemble the classically-described System A and System N transport activities in terms of their functional properties and patterns of regulation. Transport of small, aliphatic amino acids by System A subtypes (SNAT1, SNAT2, and SNAT4) is rheogenic and pH sensitive. The System N subtypes SNAT3 and SNAT5 also countertransport H(+), which may be key to their operation in reverse, and have narrower substrate profiles than do the System A subtypes. Glutamine emerges as a favored substrate throughout the family, except for SNAT4. The SLC38 transporters undoubtedly play many physiological roles including the transfer of glutamine from astrocyte to neuron in the CNS, ammonia detoxification and gluconeogenesis in the liver, and the renal response to acidosis. Probing their regulation has revealed additional roles, and recent work has considered SLC38 transporters as therapeutic targets in neoplasia.

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References

    1. J Histochem Cytochem. 1994 Jun;42(6):717-26 - PubMed
    1. Life Sci. 2000 Feb 11;66(12):1105-18 - PubMed
    1. J Biol Chem. 2002 Mar 22;277(12):10467-73 - PubMed
    1. Biochem Biophys Res Commun. 2001 Apr 27;283(1):174-8 - PubMed
    1. J Biol Chem. 2000 Feb 11;275(6):4049-54 - PubMed

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