Modulation of NF-kappaB activity by exchange of dimers
- PMID: 12820969
- DOI: 10.1016/s1097-2765(03)00227-2
Modulation of NF-kappaB activity by exchange of dimers
Abstract
Transcription factors within a family usually share the ability to recognize similar or identical consensus sites. For example, the five mammalian NF-kappaB/Rel proteins generate more than 12 dimers recognizing 9-11 nucleotide kappaB sites. Each dimer selectively regulates a few target promoters; however, several genes are redundantly induced by more than one dimer. Whether this property simply generates redundancy in target gene activation or underlies more complex regulatory mechanisms is an open issue. We show here that during dendritic cell maturation, rapidly activated dimers (e.g., p50/RelA) bound to a subset of target promoters are gradually replaced by slowly activated dimers (e.g., p52/RelB). Since the dimers have different transcriptional activity at each promoter, the dimer exchange allows fine tuning of the response over time. Further, due to the insensitivity of p52/RelB to the NF-kappaB inhibitors, the IkappaBs, dimer exchange contributes to sustained activation of selected NF-kappaB targets in spite of the resynthesis of IkappaBalpha.
Similar articles
-
Expression of different NF-kappaB pathway genes in dendritic cells (DCs) or macrophages assessed by gene expression profiling.J Cell Biochem. 2001 Aug 1-9;83(2):281-90. doi: 10.1002/jcb.1231. J Cell Biochem. 2001. PMID: 11573245
-
Differential expression of the transcription factor NF-kappaB during human mononuclear phagocyte differentiation to macrophages and dendritic cells.Biochem Biophys Res Commun. 2000 Feb 5;268(1):99-105. doi: 10.1006/bbrc.1999.2083. Biochem Biophys Res Commun. 2000. PMID: 10652220
-
Domain Stability Regulated through the Dimer Interface Controls the Formation Kinetics of a Specific NF-κB Dimer.Biochemistry. 2021 Feb 23;60(7):513-523. doi: 10.1021/acs.biochem.0c00837. Epub 2021 Feb 8. Biochemistry. 2021. PMID: 33555182
-
Dimer-specific regulatory mechanisms within the NF-κB family of transcription factors.Immunol Rev. 2012 Mar;246(1):193-204. doi: 10.1111/j.1600-065X.2011.01091.x. Immunol Rev. 2012. PMID: 22435556 Review.
-
NF-kappaB dimers in the regulation of neuronal survival.Int Rev Neurobiol. 2009;85:351-62. doi: 10.1016/S0074-7742(09)85024-1. Int Rev Neurobiol. 2009. PMID: 19607980 Review.
Cited by
-
Maturation of the Acute Hepatic TLR4/NF-κB Mediated Innate Immune Response Is p65 Dependent in Mice.Front Immunol. 2020 Aug 21;11:1892. doi: 10.3389/fimmu.2020.01892. eCollection 2020. Front Immunol. 2020. PMID: 32973783 Free PMC article.
-
Insights into the NF-κB-DNA Interaction through NMR Spectroscopy.ACS Omega. 2021 May 4;6(19):12877-12886. doi: 10.1021/acsomega.1c01299. eCollection 2021 May 18. ACS Omega. 2021. PMID: 34056439 Free PMC article.
-
Toll like Receptor signalling by Prevotella histicola activates alternative NF-κB signalling in Cystic Fibrosis bronchial epithelial cells compared to P. aeruginosa.PLoS One. 2020 Oct 8;15(10):e0235803. doi: 10.1371/journal.pone.0235803. eCollection 2020. PLoS One. 2020. PMID: 33031374 Free PMC article.
-
NFkappaB1/p50 is not required for tumor necrosis factor-stimulated growth of primary mammary epithelial cells: implications for NFkappaB2/p52 and RelB.Endocrinology. 2007 Jan;148(1):268-78. doi: 10.1210/en.2006-0500. Epub 2006 Sep 28. Endocrinology. 2007. PMID: 17008396 Free PMC article.
-
A detrimental role of RelB in mature oligodendrocytes during experimental acute encephalomyelitis.J Neuroinflammation. 2019 Jul 30;16(1):161. doi: 10.1186/s12974-019-1548-7. J Neuroinflammation. 2019. PMID: 31362762 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
