The MAGUK family protein CARD11 is essential for lymphocyte activation
- PMID: 12818158
- DOI: 10.1016/s1074-7613(03)00148-1
The MAGUK family protein CARD11 is essential for lymphocyte activation
Abstract
Members of the MAGUK family proteins cluster receptors and intracellular signaling molecules at the neuronal synapse. We report that genetic inactivation of the MAGUK family protein CARD11/Carma1/Bimp3 results in a complete block in T and B cell immunity. CARD11 is essential for antigen receptor- and PKC-mediated proliferation and cytokine production in T and B cells due to a selective defect in JNK and NFkappaB activation. Moreover, B cell proliferation and JNK activation were impaired upon stimulation of TLR4 with lipopolysaccharide, indicating that CARD11 is involved in both the innate and adaptive immune systems. Our results show that the same family of molecules are critical regulators of neuronal synapses and immune receptor signaling.
Similar articles
-
The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors.Nat Immunol. 2007 Jun;8(6):619-29. doi: 10.1038/ni1466. Epub 2007 May 7. Nat Immunol. 2007. PMID: 17486093
-
CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex.EMBO J. 2002 Oct 1;21(19):5184-94. doi: 10.1093/emboj/cdf505. EMBO J. 2002. PMID: 12356734 Free PMC article.
-
Oncogenic CARD11 mutations induce hyperactive signaling by disrupting autoinhibition by the PKC-responsive inhibitory domain.Biochemistry. 2010 Sep 28;49(38):8240-50. doi: 10.1021/bi101052d. Biochemistry. 2010. PMID: 20799731 Free PMC article.
-
NF-kappaB signaling in lymphocytes: a new cast of characters.J Cell Sci. 2004 Jan 1;117(Pt 1):31-9. doi: 10.1242/jcs.00904. J Cell Sci. 2004. PMID: 14657271 Review.
-
Reconsidering phosphorylation in the control of inducible CARD11 scaffold activity during antigen receptor signaling.Adv Biol Regul. 2021 Jan;79:100775. doi: 10.1016/j.jbior.2020.100775. Epub 2020 Dec 18. Adv Biol Regul. 2021. PMID: 33358178 Free PMC article. Review.
Cited by
-
L-CBM signaling in lymphocyte development and function.J Blood Med. 2010;1:93-104. doi: 10.2147/JBM.S9772. Epub 2010 Jun 4. J Blood Med. 2010. PMID: 22282688 Free PMC article.
-
Masking MALT1: the paracaspase's potential for cancer therapy.J Exp Med. 2009 Oct 26;206(11):2309-12. doi: 10.1084/jem.20092160. Epub 2009 Oct 19. J Exp Med. 2009. PMID: 19841088 Free PMC article.
-
Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells.Clin Exp Immunol. 2007 Jan;147(1):164-75. doi: 10.1111/j.1365-2249.2006.03249.x. Clin Exp Immunol. 2007. PMID: 17177976 Free PMC article.
-
SARS-CoV-2-Induced Immunosuppression: A Molecular Mimicry Syndrome.Glob Med Genet. 2022 Jul 14;9(3):191-199. doi: 10.1055/s-0042-1748170. eCollection 2022 Sep. Glob Med Genet. 2022. PMID: 35846107 Free PMC article.
-
N-Ethyl-N-nitrosourea mutagenesis in the mouse provides strong genetic and in vivo evidence for the role of the Caspase Recruitment Domain (CARD) of CARD-MAGUK1 in T regulatory cell development.Immunology. 2014 Mar;141(3):446-56. doi: 10.1111/imm.12207. Immunology. 2014. PMID: 24383645 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
