Interleukin-8 as a macrophage-derived mediator of angiogenesis
- PMID: 1281554
- DOI: 10.1126/science.1281554
Interleukin-8 as a macrophage-derived mediator of angiogenesis
Abstract
Angiogenic factors produced by monocytes-macrophages are involved in the pathogenesis of chronic inflammatory disorders characterized by persistent angiogenesis. The possibility was tested that interleukin-8 (IL-8), which is a cytokine that is chemotactic for lymphocytes and neutrophils, is also angiogenic. Human recombinant IL-8 was potently angiogenic when implanted in the rat cornea and induced proliferation and chemotaxis of human umbilical vein endothelial cells. Angiogenic activity present in the conditioned media of inflamed human rheumatoid synovial tissue macrophages or lipopolysaccharide-stimulated blood monocytes was equally blocked by antibodies to either IL-8 or tumor necrosis factor-alpha. An IL-8 antisense oligonucleotide specifically blocked the production of monocyte-induced angiogenic activity. These data suggest a function for macrophage-derived IL-8 in angiogenesis-dependent disorders such as rheumatoid arthritis, tumor growth, and wound repair.
Comment in
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Variability among human umbilical vein endothelial cultures.Science. 1995 Apr 21;268(5209):447-8. doi: 10.1126/science.7716553. Science. 1995. PMID: 7716553 No abstract available.
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