Evolutionary conservation of the dystrophin central rod domain

doi:10.1042/bj2870755

. 1992 Nov 1;287 ( Pt 3)(Pt 3):755-9.

doi: 10.1042/bj2870755.

Evolutionary conservation of the dystrophin central rod domain

T G Sherratt¹, T Vulliamy, P N Strong

Affiliations

PMID: 1280104
PMCID: PMC1133072
DOI: 10.1042/bj2870755

Evolutionary conservation of the dystrophin central rod domain

T G Sherratt et al. Biochem J. 1992.

. 1992 Nov 1;287 ( Pt 3)(Pt 3):755-9.

doi: 10.1042/bj2870755.

Authors

T G Sherratt¹, T Vulliamy, P N Strong

Affiliation

¹ Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K.

PMID: 1280104
PMCID: PMC1133072
DOI: 10.1042/bj2870755

Abstract

Dystrophin cDNA fragments encoding the C-terminal repeats of the central rod region have been expressed as fusion proteins. The polyclonal antisera raised to the purified fusion proteins have been characterized and neither antiserum cross-reacted with dystrophin-related protein. Antisera detected dystrophin with molecular mass close to that of the human in all terrestrial vertebrates and amphibia studied. Experiments with antisera to the N-terminal region of the dystrophin rod confirmed that epitopes to the rod region were conserved during this evolutionary period and the length of this domain remained unaltered.

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References

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[1] Am J Hum Genet. 1991 Jul;49(1):54-67 - PubMed

[2] Am J Hum Genet. 1991 Jul;49(1):54-67 - PubMed

[3] Am J Hum Genet. 1991 Feb;48(2):295-304 - PubMed

[4] Am J Hum Genet. 1991 Feb;48(2):295-304 - PubMed

[5] Nature. 1990 Jan 11;343(6254):180-2 - PubMed

[6] Nature. 1990 Jan 11;343(6254):180-2 - PubMed

[7] Nature. 1989 May 4;339(6219):55-8 - PubMed

[8] Nature. 1989 May 4;339(6219):55-8 - PubMed

[9] Nature. 1989 Apr 6;338(6215):509-11 - PubMed

[10] Nature. 1989 Apr 6;338(6215):509-11 - PubMed

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Evolutionary conservation of the dystrophin central rod domain

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Evolutionary conservation of the dystrophin central rod domain

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