Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Jun 6;300(5625):1584-7.
doi: 10.1126/science.1084677.

Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan

Stephen E Girardin  1 , Ivo G Boneca, Leticia A M Carneiro, Aude Antignac, Muguette Jéhanno, Jérôme Viala, Karsten Tedin, Muhamed-Kheir Taha, Agnes Labigne, Ulrich Zähringer, Anthony J Coyle, Peter S DiStefano, John Bertin, Philippe J Sansonetti, Dana J Philpott
Affiliations

Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan

Stephen E Girardin et al. Science. .

Abstract

Although the role of Toll-like receptors in extracellular bacterial sensing has been investigated intensively, intracellular detection of bacteria through Nod molecules remains largely uncharacterized. Here, we show that human Nod1 specifically detects a unique diaminopimelate-containing N-acetylglucosamine-N-acetylmuramic acid (GlcNAc-MurNAc) tripeptide motif found in Gram-negative bacterial peptidoglycan, resulting in activation of the transcription factor NF-kappaB pathway. Moreover, we show that in epithelial cells (which represent the first line of defense against invasive pathogens), Nod1is indispensable for intracellular Gram-negative bacterial sensing.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources