The role of antibodies and B cells in the pathogenesis of lupus nephritis
- PMID: 12778333
- DOI: 10.1007/s00281-003-0119-1
The role of antibodies and B cells in the pathogenesis of lupus nephritis
Abstract
Nephritis occurs commonly in lupus patients, and many immunological and nonimmunological factors contribute to disease expression. It is generally appreciated that glomerular immune deposit formation is an early and initiating event, although the mechanisms leading to the deposition of nephritogenic antibodies continue to be debated. Furthermore, it has recently become evident that autoantibodies expressed on B cells also play an important role in pathogenesis. This review focuses on the properties of nephritogenic autoantibodies, their mechanisms of immune deposit formation, and the contribution of B cells expressing autoantibodies to lupus nephritis.
Similar articles
-
The role of autoantibodies in the pathogenesis of lupus nephritis.Semin Nephrol. 1999 Jan;19(1):48-56. Semin Nephrol. 1999. PMID: 9952280 Review.
-
Emerging concepts regarding B cells and autoantibodies in murine lupus nephritis. B cells have multiple roles; all autoantibodies are not equal.J Am Soc Nephrol. 1996 Mar;7(3):387-96. doi: 10.1681/ASN.V73387. J Am Soc Nephrol. 1996. PMID: 8704103 Review.
-
Pathogenesis of lupus nephritis: an update.Nephrology (Carlton). 2005 Apr;10(2):174-9. doi: 10.1111/j.1440-1797.2005.00392.x. Nephrology (Carlton). 2005. PMID: 15877678 Review.
-
B cells and autoantibodies in the pathogenesis of lupus nephritis.Immunol Res. 1998;17(1-2):123-32. doi: 10.1007/BF02786437. Immunol Res. 1998. PMID: 9479574 Review.
-
Critical comparative analyses of anti-alpha-actinin and glomerulus-bound antibodies in human and murine lupus nephritis.Arthritis Rheum. 2006 Mar;54(3):914-26. doi: 10.1002/art.21622. Arthritis Rheum. 2006. PMID: 16508974
Cited by
-
Translational Mini-Review Series on B Cell-Directed Therapies: The pathogenic role of B cells in autoantibody-associated autoimmune diseases--lessons from B cell-depletion therapy.Clin Exp Immunol. 2009 Aug;157(2):191-7. doi: 10.1111/j.1365-2249.2009.03978.x. Clin Exp Immunol. 2009. PMID: 19604258 Free PMC article. Review.
-
Therapeutic implications of the anergic/postactivated status of B cells in systemic lupus erythematosus.RMD Open. 2020 Jul;6(2):e001258. doi: 10.1136/rmdopen-2020-001258. RMD Open. 2020. PMID: 32675278 Free PMC article. Review.
-
MicroRNA-146a-deficient mice develop immune complex glomerulonephritis.Sci Rep. 2019 Oct 30;9(1):15597. doi: 10.1038/s41598-019-51985-1. Sci Rep. 2019. PMID: 31666653 Free PMC article.
-
Primary Membranous Glomerulonephritis: The Role of Serum and Urine Biomarkers in Patient Management.Biomedicines. 2019 Nov 1;7(4):86. doi: 10.3390/biomedicines7040086. Biomedicines. 2019. PMID: 31683874 Free PMC article. Review.
-
Overexpression of Fkbp11, a feature of lupus B cells, leads to B cell tolerance breakdown and initiates plasma cell differentiation.Immun Inflamm Dis. 2015 Sep;3(3):265-79. doi: 10.1002/iid3.65. Epub 2015 Jun 18. Immun Inflamm Dis. 2015. PMID: 26417441 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources