Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Sep 1;168(5):538-42.
doi: 10.1164/rccm.200211-1311OC. Epub 2003 May 28.

Changes in clinical and physiologic variables predict survival in idiopathic pulmonary fibrosis

Harold R Collard  1 , Talmadge E King Jr, Becki Bucher Bartelson, Jason S Vourlekis, Marvin I Schwarz, Kevin K Brown
Affiliations

Changes in clinical and physiologic variables predict survival in idiopathic pulmonary fibrosis

Harold R Collard et al. Am J Respir Crit Care Med. .

Abstract

There is significant heterogeneity in survival time among patients with idiopathic pulmonary fibrosis. Studies of baseline clinical and physiologic variables as predictors of survival time have reported inconsistent results. We evaluated the predictive value of changes in clinical and physiologic variables over time for survival time in 81 patients with biopsy-proven idiopathic pulmonary fibrosis. Six-month changes in dyspnea score, total lung capacity, thoracic gas volume, FVC, FEV1, diffusing capacity of carbon monoxide, partial pressure of arterial oxygen, oxygen saturation, and alveolar-arterial oxygen gradient were predictive of survival time even after adjustment for baseline values. Analyses were repeated on 51 patients with 12-month change data. Twelve-month changes in dyspnea score, total lung capacity, FVC, partial pressure of arterial oxygen, oxygen saturation, and alveolar-arterial oxygen gradient were predictive of survival time after adjustment for baseline values. Evaluation of changes in clinical and physiological variables over 6 and 12 months may provide clinicians with more accurate prognostic information than baseline values alone.

PubMed Disclaimer

Comment in

  • Prognosis in idiopathic pulmonary fibrosis.
    Thabut G, Fournier M, Collard HR, Brown KK. Thabut G, et al. Am J Respir Crit Care Med. 2004 May 1;169(9):1075-6; author reply 1076. doi: 10.1164/ajrccm.169.9.962. Am J Respir Crit Care Med. 2004. PMID: 15107309 No abstract available.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

LinkOut - more resources