Inertial cavitation dose and hemolysis produced in vitro with or without Optison
- PMID: 12754072
- DOI: 10.1016/s0301-5629(03)00013-9
Inertial cavitation dose and hemolysis produced in vitro with or without Optison
Abstract
Gas-based contrast agents (CAs) increase ultrasound (US)-induced bioeffects, presumably via an inertial cavitation (IC) mechanism. The relationship between IC dose (ICD) (cumulated root mean squared [RMS] broadband noise amplitude; frequency domain) and 1.1-MHz US-induced hemolysis in whole human blood was explored with Optison; the hypothesis was that hemolysis would correlate with ICD. Four experimental series were conducted, with variable: 1. peak negative acoustic pressure (P-), 2. Optison concentration, 3. pulse duration and 4. total exposure duration and Optison concentration. P- thresholds for hemolysis and ICD were approximately 0.5 MPa. ICD and hemolysis were detected at Optison concentrations >/= 0.01 V%, and with pulse durations as low as four or two cycles, respectively. Hemolysis and ICD evolved as functions of time and Optison concentration; final hemolysis and ICD values depended on initial Optison concentration, but initial rates of change did not. Within series, hemolysis was significantly correlated with ICD; across series, the correlation was significant at p < 0.001.
Similar articles
-
The pulse length-dependence of inertial cavitation dose and hemolysis.Ultrasound Med Biol. 2003 May;29(5):739-48. doi: 10.1016/s0301-5629(03)00029-2. Ultrasound Med Biol. 2003. PMID: 12754073
-
Intravascular inertial cavitation activity detection and quantification in vivo with Optison.Ultrasound Med Biol. 2006 Oct;32(10):1601-9. doi: 10.1016/j.ultrasmedbio.2006.07.015. Ultrasound Med Biol. 2006. PMID: 17045881
-
Inertial cavitation dose produced in ex vivo rabbit ear arteries with Optison by 1-MHz pulsed ultrasound.Ultrasound Med Biol. 2006 Feb;32(2):281-8. doi: 10.1016/j.ultrasmedbio.2005.10.001. Ultrasound Med Biol. 2006. PMID: 16464673
-
Examination of inertial cavitation of Optison in producing sonoporation of chinese hamster ovary cells.Ultrasound Med Biol. 2008 Dec;34(12):2009-18. doi: 10.1016/j.ultrasmedbio.2008.05.003. Epub 2008 Aug 9. Ultrasound Med Biol. 2008. PMID: 18692296 Free PMC article.
-
Cardiac imaging using Optison.Am J Cardiol. 2000 Aug 17;86(4A):14G-18G. doi: 10.1016/s0002-9149(00)00984-x. Am J Cardiol. 2000. PMID: 10997346 Review.
Cited by
-
Nonthermal ablation of deep brain targets: A simulation study on a large animal model.Med Phys. 2016 Feb;43(2):870-82. doi: 10.1118/1.4939809. Med Phys. 2016. PMID: 26843248 Free PMC article.
-
Ultrasound with microbubbles enhances gene expression of plasmid DNA in the liver via intraportal delivery.Gene Ther. 2008 Aug;15(16):1147-55. doi: 10.1038/gt.2008.51. Epub 2008 Apr 3. Gene Ther. 2008. PMID: 18385766 Free PMC article.
-
Closed-loop control of targeted ultrasound drug delivery across the blood-brain/tumor barriers in a rat glioma model.Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):E10281-E10290. doi: 10.1073/pnas.1713328114. Epub 2017 Nov 13. Proc Natl Acad Sci U S A. 2017. PMID: 29133392 Free PMC article.
-
Application of cavitation promoting surfaces in management of acute ischemic stroke.Ultrasonics. 2013 Feb;53(2):580-7. doi: 10.1016/j.ultras.2012.10.002. Epub 2012 Oct 22. Ultrasonics. 2013. PMID: 23141666 Free PMC article.
-
Probability of cavitation for single ultrasound pulses applied to tissues and tissue-mimicking materials.Ultrasound Med Biol. 2013 Mar;39(3):449-65. doi: 10.1016/j.ultrasmedbio.2012.09.004. Epub 2013 Feb 4. Ultrasound Med Biol. 2013. PMID: 23380152 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
