doi: 10.1001/archneur.1977.00500130053010.
Aging and extrapyramidal function
- PMID: 12731
- DOI: 10.1001/archneur.1977.00500130053010
Item in Clipboard
Aging and extrapyramidal function
Arch Neurol.
1977 Jan.
Abstract
Measurements on human brain samples of some enzymes concerned with neurotransmitter synthesis suggest serious losses with age. The most severe loss found was that in striatal tyrosine hydroxylase activity, the rate-controlling enzyme in the synthesis of dopamine. Cell counts in the substantia nigra where this dopaminergic tract originates suggest that the decrease in enzyme activity is partly due to cell loss, but must largely reflect decreased activity of residual cells. It is possible that this loss may account for some of the difficulties in movement seen in aged individuals and that it might be less if pigment formation in these cells could be inhibited.
Similar articles
-
Cholinergic systems in extrapyramidal function.Res Publ Assoc Res Nerv Ment Dis. 1976;55:213-26. Res Publ Assoc Res Nerv Ment Dis. 1976. PMID: 12546 No abstract available.
-
Altered neurotransmitter synthetic enzyme activity in some extrapyramidal nuclei after lesions of the nigro-striatal dopamine projection.Life Sci. 1978 May 22;22(20):1777-82. doi: 10.1016/0024-3205(78)90592-1. Life Sci. 1978. PMID: 672427 No abstract available.
-
Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids.Nature. 1976 Oct 7;263(5577):517-9. doi: 10.1038/263517a0. Nature. 1976. PMID: 9592 No abstract available.
-
[Distributions and functions of neurotransmitters and their related enzymes in individual brain nuclei].Tanpakushitsu Kakusan Koso. 1984 Nov;29(12 Suppl):1353-63. Tanpakushitsu Kakusan Koso. 1984. PMID: 6152064 Review. Japanese. No abstract available.
-
Microanalytical methods for neuronal analysis.Physiol Rev. 1978 Oct;58(4):863-904. doi: 10.1152/physrev.1978.58.4.863. Physiol Rev. 1978. PMID: 30104 Review. No abstract available.
Cited by
-
Age-related decline in motor behavior and striatal dopamine transporter in cynomolgus monkeys.J Neural Transm (Vienna). 2012 Aug;119(8):943-52. doi: 10.1007/s00702-012-0770-6. Epub 2012 Feb 11. J Neural Transm (Vienna). 2012. PMID: 22327353
-
Why is delirium more frequent in the elderly?Neurol Sci. 2021 Aug;42(8):3491-3503. doi: 10.1007/s10072-021-05339-3. Epub 2021 May 24. Neurol Sci. 2021. PMID: 34031797 Free PMC article.
-
Stability of neuron number in the subthalamic and entopeduncular nuclei of the ageing mouse brain.J Anat. 1991 Dec;179:67-73. J Anat. 1991. PMID: 1817143 Free PMC article.
-
The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method.J Neurol Neurosurg Psychiatry. 1991 Jan;54(1):30-3. doi: 10.1136/jnnp.54.1.30. J Neurol Neurosurg Psychiatry. 1991. PMID: 2010756 Free PMC article.
-
Early Parkinson's disease: what is the best approach to treatment.Drugs Aging. 2000 Sep;17(3):165-81. doi: 10.2165/00002512-200017030-00002. Drugs Aging. 2000. PMID: 11043817 Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
