Review
doi: 10.1038/nrm1105.
Ras proteins: different signals from different locations
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- PMID: 12728271
- DOI: 10.1038/nrm1105
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Review
Ras proteins: different signals from different locations
Nat Rev Mol Cell Biol.
2003 May.
Abstract
Ras signalling has classically been thought to occur exclusively at the inner surface of a relatively uniform plasma membrane. Recent studies have shown that Ras proteins interact dynamically with specific microdomains of the plasma membrane as well as with other internal cell membranes. These different membrane microenvironments modulate Ras signal output and highlight the complex interplay between Ras location and function.
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