Review
doi: 10.1038/nrc1074.
5-fluorouracil: mechanisms of action and clinical strategies
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- PMID: 12724731
- DOI: 10.1038/nrc1074
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Review
5-fluorouracil: mechanisms of action and clinical strategies
Nat Rev Cancer.
2003 May.
Abstract
5-fluorouracil (5-FU) is widely used in the treatment of cancer. Over the past 20 years, increased understanding of the mechanism of action of 5-FU has led to the development of strategies that increase its anticancer activity. Despite these advances, drug resistance remains a significant limitation to the clinical use of 5-FU. Emerging technologies, such as DNA microarray profiling, have the potential to identify novel genes that are involved in mediating resistance to 5-FU. Such target genes might prove to be therapeutically valuable as new targets for chemotherapy, or as predictive biomarkers of response to 5-FU-based chemotherapy.
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