The methyl-CpG binding domain and the evolving role of DNA methylation in animals
- PMID: 12711219
- DOI: 10.1016/S0168-9525(03)00080-5
The methyl-CpG binding domain and the evolving role of DNA methylation in animals
Abstract
DNA methylation occurs in bacteria, fungi, plants and animals, however its role varies widely among different organisms. Even within animal genomes, methylation patterns vary substantially from undetectable in nematodes, to global methylation in vertebrate genomes. The number and variety of proteins containing methyl-CpG binding domains (MBDs) that are encoded in animal genomes also varies, with a general correlation between the extent of genomic methylation and the number of MBD proteins. We describe here the evolution of the MBD proteins and argue that the vertebrate MBD complement evolved to exploit the benefits and protect against the dangers of a globally methylated genome.
Similar articles
-
Methyl-CpG-binding proteins. Targeting specific gene repression.Eur J Biochem. 2001 Jan;268(1):1-6. doi: 10.1046/j.1432-1327.2001.01869.x. Eur J Biochem. 2001. PMID: 11121095 Review.
-
ReCoGnizing methylated DNA.Nat Struct Biol. 2001 Jul;8(7):575-7. doi: 10.1038/89593. Nat Struct Biol. 2001. PMID: 11427881 No abstract available.
-
Methylation-dependent and -independent genomic targeting principles of the MBD protein family.Cell. 2013 Apr 11;153(2):480-92. doi: 10.1016/j.cell.2013.03.011. Cell. 2013. PMID: 23582333
-
Methyl-CpG-binding domain proteins in plants: interpreters of DNA methylation.Trends Plant Sci. 2007 Feb;12(2):80-5. doi: 10.1016/j.tplants.2006.12.004. Epub 2007 Jan 8. Trends Plant Sci. 2007. PMID: 17208509 Review.
-
Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer.EMBO J. 2003 Dec 1;22(23):6335-45. doi: 10.1093/emboj/cdg604. EMBO J. 2003. PMID: 14633992 Free PMC article.
Cited by
-
5-methyl-cytosine and 5-hydroxy-methyl-cytosine in the genome of Biomphalaria glabrata, a snail intermediate host of Schistosoma mansoni.Parasit Vectors. 2013 Jun 6;6:167. doi: 10.1186/1756-3305-6-167. Parasit Vectors. 2013. PMID: 23742053 Free PMC article.
-
Epigenetics of the failing heart.Heart Fail Rev. 2015 Jul;20(4):435-59. doi: 10.1007/s10741-015-9483-x. Heart Fail Rev. 2015. PMID: 25847519 Review.
-
Structure and function insights into the NuRD chromatin remodeling complex.Cell Mol Life Sci. 2015 Jul;72(13):2491-507. doi: 10.1007/s00018-015-1880-8. Epub 2015 Mar 22. Cell Mol Life Sci. 2015. PMID: 25796366 Free PMC article. Review.
-
Genomic specification and epigenetic regulation of eukaryotic DNA replication origins.EMBO J. 2004 Nov 10;23(22):4365-70. doi: 10.1038/sj.emboj.7600450. Epub 2004 Oct 28. EMBO J. 2004. PMID: 15510221 Free PMC article. Review.
-
Functional diversification of the nematode mbd2/3 gene between Pristionchus pacificus and Caenorhabditis elegans.BMC Genet. 2007 Aug 28;8:57. doi: 10.1186/1471-2156-8-57. BMC Genet. 2007. PMID: 17725827 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases