Wnt signaling and pulmonary fibrosis

doi:10.1016/S0002-9440(10)64271-X

Review

. 2003 May;162(5):1393-7.

doi: 10.1016/S0002-9440(10)64271-X.

Wnt signaling and pulmonary fibrosis

Edward E Morrisey¹

Affiliations

PMID: 12707021
PMCID: PMC1851190
DOI: 10.1016/S0002-9440(10)64271-X

Review

Wnt signaling and pulmonary fibrosis

Edward E Morrisey. Am J Pathol. 2003 May.

. 2003 May;162(5):1393-7.

doi: 10.1016/S0002-9440(10)64271-X.

Author

Edward E Morrisey¹

Affiliation

¹ Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. emorrise@med.med.upenn.edu

PMID: 12707021
PMCID: PMC1851190
DOI: 10.1016/S0002-9440(10)64271-X

No abstract available

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Figures

**Figure 1.**
Autocrine and paracrine Wnt signaling in the lung. Several Wnt ligands are expressed in either the epithelium or mesenchyme during development and in the adult. β-catenin is expressed in both alveolar epithelium as well as the adjacent mesenchyme. Epithelial-mesenchymal signaling via Wnts may regulate diverse aspects of lung development and injury repair.

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Comment on

Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis.
Chilosi M, Poletti V, Zamò A, Lestani M, Montagna L, Piccoli P, Pedron S, Bertaso M, Scarpa A, Murer B, Cancellieri A, Maestro R, Semenzato G, Doglioni C. Chilosi M, et al. Am J Pathol. 2003 May;162(5):1495-502. doi: 10.1016/s0002-9440(10)64282-4. Am J Pathol. 2003. PMID: 12707032 Free PMC article.

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References

1. Murphy A, O’Sullivan BJ: Familial fibrosing alveolitis. Ir J Med Sci 1981, 150:204-209 - PubMed
1. Bitterman PB, Rennard SI, Keogh BA, Wewers MD, Adelberg S, Crystal RG: Familial idiopathic pulmonary fibrosis. Evidence of lung inflammation in unaffected family members. N Engl J Med 1986, 314:1343-1347 - PubMed
1. Mageto YN, Raghu G: Genetic predisposition of idiopathic pulmonary fibrosis. Curr Opin Pulm Med 1997, 3:336-340 - PubMed
1. Kapanci Y, Desmouliere A, Pache JC, Redard M, Gabbiani G: Cytoskeletal protein modulation in pulmonary alveolar myofibroblasts during idiopathic pulmonary fibrosis. Possible role of transforming growth factor beta and tumor necrosis factor alpha. Am J Respir Crit Care Med 1995, 152:2163-2169 - PubMed
1. Khalil N, O’Connor RN, Unruh HW, Warren PW, Flanders KC, Kemp A, Bereznay OH, Greenberg AH: Increased production and immunohistochemical localization of transforming growth factor-beta in idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol 1991, 5:155-162 - PubMed

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[1] Murphy A, O’Sullivan BJ: Familial fibrosing alveolitis. Ir J Med Sci 1981, 150:204-209 - PubMed

[2] Murphy A, O’Sullivan BJ: Familial fibrosing alveolitis. Ir J Med Sci 1981, 150:204-209 - PubMed

[3] Bitterman PB, Rennard SI, Keogh BA, Wewers MD, Adelberg S, Crystal RG: Familial idiopathic pulmonary fibrosis. Evidence of lung inflammation in unaffected family members. N Engl J Med 1986, 314:1343-1347 - PubMed

[4] Bitterman PB, Rennard SI, Keogh BA, Wewers MD, Adelberg S, Crystal RG: Familial idiopathic pulmonary fibrosis. Evidence of lung inflammation in unaffected family members. N Engl J Med 1986, 314:1343-1347 - PubMed

[5] Mageto YN, Raghu G: Genetic predisposition of idiopathic pulmonary fibrosis. Curr Opin Pulm Med 1997, 3:336-340 - PubMed

[6] Mageto YN, Raghu G: Genetic predisposition of idiopathic pulmonary fibrosis. Curr Opin Pulm Med 1997, 3:336-340 - PubMed

[7] Kapanci Y, Desmouliere A, Pache JC, Redard M, Gabbiani G: Cytoskeletal protein modulation in pulmonary alveolar myofibroblasts during idiopathic pulmonary fibrosis. Possible role of transforming growth factor beta and tumor necrosis factor alpha. Am J Respir Crit Care Med 1995, 152:2163-2169 - PubMed

[8] Kapanci Y, Desmouliere A, Pache JC, Redard M, Gabbiani G: Cytoskeletal protein modulation in pulmonary alveolar myofibroblasts during idiopathic pulmonary fibrosis. Possible role of transforming growth factor beta and tumor necrosis factor alpha. Am J Respir Crit Care Med 1995, 152:2163-2169 - PubMed

[9] Khalil N, O’Connor RN, Unruh HW, Warren PW, Flanders KC, Kemp A, Bereznay OH, Greenberg AH: Increased production and immunohistochemical localization of transforming growth factor-beta in idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol 1991, 5:155-162 - PubMed

[10] Khalil N, O’Connor RN, Unruh HW, Warren PW, Flanders KC, Kemp A, Bereznay OH, Greenberg AH: Increased production and immunohistochemical localization of transforming growth factor-beta in idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol 1991, 5:155-162 - PubMed

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Wnt signaling and pulmonary fibrosis

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