Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2003 May 8;341(3):217-20.
doi: 10.1016/s0304-3940(03)00187-3.

Facilitation of long-term object recognition memory by pretraining administration of diphenyl diselenide in mice

Renato M Rosa  1 , Debora G Flores, Helmoz R Appelt, Antônio Luiz Braga, João Antônio Pêgas Henriques, Rafael Roesler
Affiliations
Comparative Study

Facilitation of long-term object recognition memory by pretraining administration of diphenyl diselenide in mice

Renato M Rosa et al. Neurosci Lett. .

Abstract

Selenium compounds display antioxidant and neuroprotective properties. Diphenyl diselenide (PhSe)(2) is an organic selenium compound that affects a number of neuronal processes. The aim of the present study was to evaluate the effects of the systemic administration of (PhSe)(2) on novel object recognition memory in mice. Adult male CF1 mice were given an i.p. injection of (PhSe)(2) (0.2, 1.0, 5.0, or 25.0 micromol/kg) 30 min before training in an object recognition task. (PhSe)(2) did not affect short-term memory or the total time exploring both objects, but induced a facilitation of retention measured 24 h after training. The present findings show that systemic administration of (PhSe)(2) induces a facilitation of formation of long-term object recognition memory.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

LinkOut - more resources