A genomic view of the human-Bacteroides thetaiotaomicron symbiosis
- PMID: 12663928
- DOI: 10.1126/science.1080029
A genomic view of the human-Bacteroides thetaiotaomicron symbiosis
Abstract
The human gut is colonized with a vast community of indigenous microorganisms that help shape our biology. Here, we present the complete genome sequence of the Gram-negative anaerobe Bacteroides thetaiotaomicron, a dominant member of our normal distal intestinal microbiota. Its 4779-member proteome includes an elaborate apparatus for acquiring and hydrolyzing otherwise indigestible dietary polysaccharides and an associated environment-sensing system consisting of a large repertoire of extracytoplasmic function sigma factors and one- and two-component signal transduction systems. These and other expanded paralogous groups shed light on the molecular mechanisms underlying symbiotic host-bacterial relationships in our intestine.
Comment in
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Microbiology. The thin line between gut commensal and pathogen.Science. 2003 Mar 28;299(5615):1999-2002. doi: 10.1126/science.1083534. Science. 2003. PMID: 12663906 No abstract available.
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