Prenatal origin of TEL-AML1-positive acute lymphoblastic leukemia in children born in California
- PMID: 12661004
- DOI: 10.1002/gcc.10199
Prenatal origin of TEL-AML1-positive acute lymphoblastic leukemia in children born in California
Abstract
Acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer. The peak incidence of ALL between ages 2 and 5 is accounted for by one subtype, referred to as common acute lymphoblastic leukemia (cALL). About 25% of cALL patients have the TEL-AML1 gene fusion derived from the t(12;21) chromosomal translocation. Recent evidence from retrospective analysis of neonatal blood spots (Guthrie cards) in Europe has demonstrated that this chromosome translocation may arise prenatally. The aim of our study was to determine whether TEL-AML1 fusions arise prenatally in a U.S. population of cALL patients. TEL-AML1-positive cALL cases (n = 14) were identified by fluorescence in situ hybridization, and the genomic breakpoints were identified by a streamlined long-distance PCR approach and sequenced. Clonotypic primers were designed for each patient breakpoint, and a nested PCR assay was used to determine the presence of the TEL-AML1 fusion sequence in neonatal Guthrie cards. Seven of 14 cases demonstrated clonotypic sequences on the archival Guthrie cards. The oldest patient that was positive was 6.7 years old at the time of diagnosis of leukemia. These results confirm previously published findings of a prenatal origin of TEL-AML1 in Europe by demonstrating its occurrence in a California-born population. Secondary changes were also similar to those described previously, with deletion of the second TEL allele being the most common. Other secondary changes included duplication of the fusion gene, trisomy 21, and monosomy X.
Copyright 2003 Wiley-Liss, Inc.
Similar articles
-
Chromosomal changes detected by fluorescence in situ hybridization in patients with acute lymphoblastic leukemia.Chin Med J (Engl). 2003 Sep;116(9):1298-303. Chin Med J (Engl). 2003. PMID: 14527352
-
Fluorescence in situ hybridization study of TEL/AML1 fusion and other abnormalities involving TEL and AML1 genes. Correlation with cytogenetic findings and prognostic value in children with acute lymphocytic leukemia.Haematologica. 2001 Dec;86(12):1245-53. Haematologica. 2001. PMID: 11726315
-
Interphase FISH on TEL/AML1 positive acute lymphoblastic leukemia relapses--analysis of clinical relevance of additional TEL and AML1 copy number changes.Eur J Haematol. 2009 Nov;83(5):420-32. doi: 10.1111/j.1600-0609.2009.01315.x. Epub 2009 Jul 6. Eur J Haematol. 2009. PMID: 19594616 Clinical Trial.
-
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.Oncogene. 2004 May 24;23(24):4275-83. doi: 10.1038/sj.onc.1207672. Oncogene. 2004. PMID: 15156184 Review.
-
[The role of TEL and AML1 genes in the pathogenesis of hematologic malignancies].Cas Lek Cesk. 2001 Mar 15;140(5):131-7. Cas Lek Cesk. 2001. PMID: 11347199 Review. Czech.
Cited by
-
Prenatal origin of childhood AML occurs less frequently than in childhood ALL.BMC Cancer. 2006 Apr 21;6:100. doi: 10.1186/1471-2407-6-100. BMC Cancer. 2006. PMID: 16630339 Free PMC article.
-
Spatial-Temporal Cluster Analysis of Childhood Cancer in California.Epidemiology. 2020 Mar;31(2):214-223. doi: 10.1097/EDE.0000000000001121. Epidemiology. 2020. PMID: 31596791 Free PMC article.
-
The Diverse Roles of ETV6 Alterations in B-Lymphoblastic Leukemia and Other Hematopoietic Cancers.Adv Exp Med Biol. 2024;1459:291-320. doi: 10.1007/978-3-031-62731-6_13. Adv Exp Med Biol. 2024. PMID: 39017849 Review.
-
Frequency of Cytogenetic Findings and its Effect on the Outcome of Pediatric Acute Lymphoblastic Leukemia.Med Arch. 2019 Oct;73(5):311-315. doi: 10.5455/medarh.2019.73.311-315. Med Arch. 2019. PMID: 31819303 Free PMC article.
-
History of Parvovirus B19 infection is associated with a DNA methylation signature in childhood acute lymphoblastic leukemia.Epigenetics. 2011 Dec;6(12):1436-43. doi: 10.4161/epi.6.12.18464. Epigenetics. 2011. PMID: 22139573 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous