Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon
- PMID: 12628169
- DOI: 10.1016/s0896-6273(03)00088-6
Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon
Abstract
Mutant mice lacking the central region of the presynaptic active zone protein Bassoon were generated to establish the role of this protein in the assembly and function of active zones as sites of synaptic vesicle docking and fusion. Our data show that the loss of Bassoon causes a reduction in normal synaptic transmission, which can be attributed to the inactivation of a significant fraction of glutamatergic synapses. At these synapses, vesicles are clustered and docked in normal numbers but are unable to fuse. Phenotypically, the loss of Bassoon causes spontaneous epileptic seizures. These data show that Bassoon is not essential for synapse formation but plays an essential role in the regulated neurotransmitter release from a subset of glutamatergic synapses.
Comment in
-
Bassoon's part in two presynaptic orchestras.Neuron. 2003 Mar 6;37(5):728-30. doi: 10.1016/s0896-6273(03)00121-1. Neuron. 2003. PMID: 12628163
Similar articles
-
The presynaptic active zone protein bassoon is essential for photoreceptor ribbon synapse formation in the retina.Neuron. 2003 Mar 6;37(5):775-86. doi: 10.1016/s0896-6273(03)00086-2. Neuron. 2003. PMID: 12628168
-
Bassoon speeds vesicle reloading at a central excitatory synapse.Neuron. 2010 Nov 18;68(4):710-23. doi: 10.1016/j.neuron.2010.10.026. Neuron. 2010. PMID: 21092860 Free PMC article.
-
Bassoon and the synaptic ribbon organize Ca²+ channels and vesicles to add release sites and promote refilling.Neuron. 2010 Nov 18;68(4):724-38. doi: 10.1016/j.neuron.2010.10.027. Neuron. 2010. PMID: 21092861 Free PMC article.
-
CAST and ELKS proteins: structural and functional determinants of the presynaptic active zone.J Biochem. 2010 Aug;148(2):131-7. doi: 10.1093/jb/mvq065. Epub 2010 Jun 24. J Biochem. 2010. PMID: 20581014 Review.
-
Development of identified neuronal types and of specific synaptic connections in slice cultures of rat hippocampus.Prog Neurobiol. 1995 Apr;45(6):vii-xxviii. doi: 10.1016/0301-0082(95)90872-h. Prog Neurobiol. 1995. PMID: 7624484 Review. No abstract available.
Cited by
-
A systems approach identifies networks and genes linking sleep and stress: implications for neuropsychiatric disorders.Cell Rep. 2015 May 5;11(5):835-48. doi: 10.1016/j.celrep.2015.04.003. Epub 2015 Apr 23. Cell Rep. 2015. PMID: 25921536 Free PMC article.
-
Rapid activation of dormant presynaptic terminals by phorbol esters.J Neurosci. 2010 Jul 28;30(30):10048-60. doi: 10.1523/JNEUROSCI.1159-10.2010. J Neurosci. 2010. PMID: 20668189 Free PMC article.
-
TrkB/BDNF-dependent striatal plasticity and behavior in a genetic model of epilepsy: modulation by valproic acid.Neuropsychopharmacology. 2010 Jun;35(7):1531-40. doi: 10.1038/npp.2010.23. Epub 2010 Mar 3. Neuropsychopharmacology. 2010. PMID: 20200504 Free PMC article.
-
Mechanisms controlling the trafficking, localization, and abundance of presynaptic Ca2+ channels.Front Mol Neurosci. 2023 Jan 13;15:1116729. doi: 10.3389/fnmol.2022.1116729. eCollection 2022. Front Mol Neurosci. 2023. PMID: 36710932 Free PMC article. Review.
-
Rare predicted loss of function alleles in Bassoon (BSN) are associated with obesity.NPJ Genom Med. 2023 Oct 21;8(1):33. doi: 10.1038/s41525-023-00376-7. NPJ Genom Med. 2023. PMID: 37865656 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
