Hypergammaglobulinemia and autoantibody induction mechanisms in viral infections
- PMID: 12627229
- DOI: 10.1038/ni911
Hypergammaglobulinemia and autoantibody induction mechanisms in viral infections
Abstract
Polyclonal hypergammaglobulinemia is a characteristic of chronic inflammatory conditions, including persisting viral infections and autoimmune diseases. Here we have studied hypergammaglobulinemia in mice infected with lymphocytic choriomeningitis virus (LCMV), which induces nonspecific immunoglobulins as a result of switching natural IgM specificities to IgG. The process is dependent on help from CD4+ T cells that specifically recognize LCMV peptides presented by B cells on major histocompatibility complex class II molecules. Thus, hypergammaglobulinemia may arise when specific helper T cells recognize B cells that have processed viral antigens irrespective of the B cell receptor specificity. This nonspecific B cell activation may contribute to antibody-mediated autoimmunity.
Comment in
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On the implications of polyclonal B cell activation.Nat Immunol. 2003 Oct;4(10):931-2; author reply 932. doi: 10.1038/ni1003-931. Nat Immunol. 2003. PMID: 14515119 No abstract available.
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