doi: 10.1016/s0140-6736(03)12509-3.
Effect of ibuprofen on cardioprotective effect of aspirin
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- PMID: 12598144
- DOI: 10.1016/s0140-6736(03)12509-3
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Effect of ibuprofen on cardioprotective effect of aspirin
Lancet.
.
Abstract
Treatment with ibuprofen might limit the cardioprotective effects of aspirin. We aimed to assess whether patients with known cardiovascular disease who take low-dose aspirin and ibuprofen have increased risk of cardiovascular mortality. We studied 7107 patients who were discharged after first admission for cardiovascular disease between April, 1989, and April, 1997, and who were prescribed low-dose aspirin (<325 mg/day) and survived for at least 1 month. Compared with those who used aspirin alone, patients taking aspirin plus ibuprofen had an increased risk of all-cause mortality (adjusted hazard ratio 1.93, 95% CI 1.30-2.87, p=0.0011) and cardiovascular mortality (1.73, 1.05-2.84, p=0.0305). Our finding lends support to the hypothesis that ibuprofen may interact with the cardioprotective effects of aspirin, at least in patients with established cardiovascular disease.
Comment in
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Parsing an enigma: the pharmacodynamics of aspirin resistance.Lancet. 2003 Feb 15;361(9357):542-4. doi: 10.1016/S0140-6736(03)12560-3. Lancet. 2003. PMID: 12598136 No abstract available.
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Effect of ibuprofen on cardioprotective effect of aspirin.Lancet. 2003 May 3;361(9368):1558-9; author reply 1559. doi: 10.1016/S0140-6736(03)13187-X. Lancet. 2003. PMID: 12737885 No abstract available.
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Effect of ibuprofen on cardioprotective effect of aspirin.Lancet. 2003 May 3;361(9368):1559; author reply 1559. doi: 10.1016/S0140-6736(03)13188-1. Lancet. 2003. PMID: 12737887 No abstract available.
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Effect of ibuprofen on cardioprotective effect of aspirin.Lancet. 2003 May 3;361(9368):1560; author reply 1561. doi: 10.1016/S0140-6736(03)13191-1. Lancet. 2003. PMID: 12737889 No abstract available.
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Effect of ibuprofen on cardioprotective effect of aspirin.Lancet. 2003 May 3;361(9368):1560; author reply 1561. doi: 10.1016/S0140-6736(03)13193-5. Lancet. 2003. PMID: 12737890 No abstract available.
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Effect of ibuprofen on cardioprotective effect of aspirin.Lancet. 2003 May 3;361(9368):1560-1; author reply 1561. doi: 10.1016/S0140-6736(03)13194-7. Lancet. 2003. PMID: 12737891 No abstract available.
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