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. 2003 Feb;18(2):301-12.
doi: 10.1016/s1074-7613(03)00029-3.

Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway

Kazuki Kuroda  1 , Hua Han, Shoichi Tani, Kenji Tanigaki, Tin Tun, Takahisa Furukawa, Yoshihito Taniguchi, Hisanori Kurooka, Yoshio Hamada, Shinya Toyokuni, Tasuku Honjo
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Free article

Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway

Kazuki Kuroda et al. Immunity. 2003 Feb.
Free article

Abstract

We found that Msx2-interacting nuclear target protein (MINT) competed with the intracellular region of Notch for binding to a DNA binding protein RBP-J and suppressed the transactivation activity of Notch signaling. Although MINT null mutant mice were embryonic lethal, MINT-deficient splenic B cells differentiated about three times more efficiently into marginal zone B cells with a concomitant reduction of follicular B cells. MINT is expressed in a cell-specific manner: high in follicular B cells and low in marginal zone B cells. Since Notch signaling directs differentiation of marginal zone B lymphocytes and suppresses that of follicular B lymphocytes in mouse spleen, the results indicate that high levels of MINT negatively regulate Notch signaling and block differentiation of precursor B cells into marginal zone B cells. MINT may serve as a functional homolog of Drosophila Hairless.

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