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. 2003 Feb;18(2):185-92.
doi: 10.1016/s1074-7613(03)00026-8.

Regulation of anti-phosphatidylserine antibodies

Hui Li  1 , Yufei Jiang, Hong Cao, Marko Radic, Eline Luning Prak, Martin Weigert
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Free article

Regulation of anti-phosphatidylserine antibodies

Hui Li et al. Immunity. 2003 Feb.
Free article

Abstract

The degree of heavy chain (H) editing, the types of Vkappa editors, and the pattern of Jkappa usage are correlated with a range of the affinity of anti-DNA. This range was determined by the number and location of arginine (R) residues in the VH. We, here, changed a key arginine residue in the VH of anti-DNA transgene to glycine, which sharply reduces the affinity for dsDNA. However, complete reversion of this anti-DNA to germline enhances the affinity for phosphatidylserine (PS). The B cells of this low-affinity anti-DNA and anti-PS transgenic mouse are tightly regulated by receptor editing. Thus, anti-PS B cells are another example of a constitutive self-antigen regulated in the bone marrow.

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