doi: 10.1038/nn1020.
An evolutionarily conserved dileucine motif in Shal K+ channels mediates dendritic targeting
Affiliations
- PMID: 12592409
- DOI: 10.1038/nn1020
Item in Clipboard
An evolutionarily conserved dileucine motif in Shal K+ channels mediates dendritic targeting
Nat Neurosci.
2003 Mar.
Erratum in
- Nat Neurosci. 2003 Aug;6(8):899
Abstract
The molecular mechanisms underlying polarized sorting of proteins in neurons are poorly understood. Here we report the identification of a 16 amino-acid, dileucine-containing motif that mediates dendritic targeting in a variety of neuronal cell types in slices of rat brain. This motif is present in the carboxy (C) termini of Shal-family K+ channels and is highly conserved from C. elegans to humans. It is necessary for dendritic targeting of potassium channel Kv4.2 and is sufficient to target the axonally localized channels Kv1.3 and Kv1.4 to the dendrites. It can also mediate dendritic targeting of a non-channel protein, CD8.
Similar articles
-
A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels.Science. 2003 Aug 1;301(5633):646-9. doi: 10.1126/science.1086998. Science. 2003. PMID: 12893943
-
Mossy fibre contact triggers the targeting of Kv4.2 potassium channels to dendrites and synapses in developing cerebellar granule neurons.J Neurochem. 2004 May;89(4):897-907. doi: 10.1111/j.1471-4159.2004.02368.x. J Neurochem. 2004. PMID: 15140189
-
Residues within the myristoylation motif determine intracellular targeting of the neuronal Ca2+ sensor protein KChIP1 to post-ER transport vesicles and traffic of Kv4 K+ channels.J Cell Sci. 2003 Dec 1;116(Pt 23):4833-45. doi: 10.1242/jcs.00803. J Cell Sci. 2003. PMID: 14600268
-
Surface expression of Kv1 voltage-gated K+ channels is governed by a C-terminal motif.Trends Cardiovasc Med. 2000 Oct;10(7):317-20. doi: 10.1016/s1050-1738(01)00078-0. Trends Cardiovasc Med. 2000. PMID: 11343973 Review.
-
Molecular physiology and modulation of somatodendritic A-type potassium channels.Mol Cell Neurosci. 2004 Dec;27(4):343-69. doi: 10.1016/j.mcn.2004.06.011. Mol Cell Neurosci. 2004. PMID: 15555915 Review.
Cited by
-
Coupling mechanical forces to electrical signaling: molecular motors and the intracellular transport of ion channels.Neuroscientist. 2013 Apr;19(2):145-59. doi: 10.1177/1073858412456088. Epub 2012 Aug 20. Neuroscientist. 2013. PMID: 22910031 Free PMC article. Review.
-
Kv1.3 channel gene-targeted deletion produces "Super-Smeller Mice" with altered glomeruli, interacting scaffolding proteins, and biophysics.Neuron. 2004 Feb 5;41(3):389-404. doi: 10.1016/s0896-6273(03)00844-4. Neuron. 2004. PMID: 14766178 Free PMC article.
-
Structural basis of gating modulation of Kv4 channel complexes.Nature. 2021 Nov;599(7883):158-164. doi: 10.1038/s41586-021-03935-z. Epub 2021 Sep 22. Nature. 2021. PMID: 34552243 Free PMC article.
-
A novel phenylalanine-based targeting signal directs telencephalin to neuronal dendrites.J Neurosci. 2005 Feb 2;25(5):1122-31. doi: 10.1523/JNEUROSCI.3853-04.2005. J Neurosci. 2005. PMID: 15689548 Free PMC article.
-
Myosin-dependent targeting of transmembrane proteins to neuronal dendrites.Nat Neurosci. 2009 May;12(5):568-76. doi: 10.1038/nn.2318. Epub 2009 Apr 19. Nat Neurosci. 2009. PMID: 19377470 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Research Materials
