Review
doi: 10.1016/s1471-4922(02)00053-3.
T cells as mediators of protective immunity against liver stages of Plasmodium
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- PMID: 12586477
- DOI: 10.1016/s1471-4922(02)00053-3
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Review
T cells as mediators of protective immunity against liver stages of Plasmodium
Trends Parasitol.
2003 Feb.
Abstract
T cells from different subsets play a major role in protective immunity against pre-erythrocytic stages of malaria parasites. Exposure of humans and animals to malaria sporozoites induces (alphabeta CD8(+) and CD4(+) T cells specific for antigens expressed in pre-erythrocytic stages of Plasmodium. These T cells inhibit parasite development in the liver, and immunization with subunit vaccines expressing the respective antigenic moieties confers protection against sporozoite challenge. gammadelta and natural killer T cells can also play a role in protective immunity. Recent studies with mice transgenic for the alphabeta T-cell receptor have revealed the existence of complex mechanisms regulating the induction and development of these responses.
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