Review
doi: 10.1016/s1359-6446(02)02562-x.
Nuclear transport as a target for cell growth
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- PMID: 12565010
- DOI: 10.1016/s1359-6446(02)02562-x
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Review
Nuclear transport as a target for cell growth
Drug Discov Today.
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Abstract
The function of many key proteins and transcription factors involved in cell growth can be regulated by their cellular localization. Such proteins include the tumor suppressor p53 and the nuclear factor kappaB. Although the idea of trapping such proteins in either the nucleus or cytoplasm has been introduced as a potential therapeutic target, only two nuclear transport inhibitors have been reported. Here, we explore the roles of small-molecule inhibitors that cause target proteins to sequester in either the nucleus or cytoplasm. Methods of artificially targeting proteins to the nucleus or cytoplasm using peptide aptamer technology are also discussed.
Comment in
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Nuclear transport as a target for cancer therapies.Drug Discov Today. 2003 Mar 15;8(6):249. doi: 10.1016/s1359-6446(03)02628-x. Drug Discov Today. 2003. PMID: 12623236 No abstract available.
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